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Pharmaceutics > Block 4 > Flashcards

Block 4 Flashcards

1
Q

Novel Injectables

For IM injections, how much can you inject?

A

2-5mL, larger than subQ inj

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2
Q

Novel Injectables

For SubQ injection, how much can you inject?

A

1-2mL, smaller than IM inj

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3
Q

Novel Injectables

IM vs SubQ, which one allows mild irritants to be used?

A

IM

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4
Q

Novel Injectables

IM vs SubQ, which one only allows non-irritating substances?

A

SubQ

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5
Q

Novel Injectables

Why does IM inj allow mild irritants?

A

Muscles are more vascular and have fewer sensory nerves

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6
Q

Novel Injectables

What is the primary route of delivery for subQ inj?

A

Protein-based drugs

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7
Q

Which novel inj solution allows controlled release to take place for months - year?

A

Polymer-based in situ forming systems

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8
Q

Which novel inj solution has the shortest controlled release profile?

A

Oil-based solution

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9
Q

What is the rate limiting step in oil-based novel injections?

A

Dissolution

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10
Q

What is an iontophoresis?

A

Migration of ionic drug into tissue by electric current

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11
Q

What are some advantages of iontophoresis?

A
  1. Controlled delivery rate
  2. Eliminates GI issues
  3. Avoid risk of infection, inflammation, etc
  4. Enhanced pt compliance
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12
Q

What are some disadvantages of iontophoresis?

A

Irritation at high current densities

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13
Q

What is a phonophoresis?

A

Transport of drug thru tissue via ultrasound

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14
Q

With phonophoresis, what is the drug usually mixed with?

A

Coupling agent (gel, cream, etc)

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15
Q

Which layer of the skin is involved with phonophoresis?

A

Stratum corneum

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16
Q

Explain the caviation MOA of phonophoresis

A

Formation of small air bubbles leading to disordering of lipid bilayer forming a channel

17
Q

Explain the microstreaming MOA of phonophoresis

A

Efficient mixing by inducing eddies, which enhances dissolution

18
Q

Explain the heat generation MOA of phonophoresis

A

Converts ultrasound energy to heat energy

19
Q

“Pharmacy on a Chip” what is this?

A

Device designed to deliver 200 months (16yrs) worth of progestin for birth control

20
Q

“Accordion Pill” what is this?

A

Biodegradable polymeric film that is folded to an accordion shape stuffed into a capsule

Retains in stomach for 8 to 12 hours (up to 550mg)

21
Q

“Sushi Implant” what is this?

A

Treats T1DM, artificial pancreas

22
Q

What are the components of therapeutic nanoparticles?

A
  1. Targeting mechanism
  2. Destructive mechanism
  3. Molecular packaging
23
Q

What is the size of a nanoparticle?

A

10^-9 m = 1nm

24
Q

In a liposome, what are hydrophilic and hydrophobic drug loaded at?

A

Hydrophilic - core

Hydrophobic - lipid bilayer

25
Q

MOA Doxil (Doxorubicin)?

A

Topoisomerase II inhibitor

26
Q

What is included in a batch analysis size technique?

A

DLS + SLS

27
Q

DLS + SLS is found in what sizing technique?

A

Batch analysis

28
Q

What is included in a separation-based analysis for sizing techniques?

A

FFF, LC, and AUC

29
Q

FFF, LC, and AUC is found in what sizing technique?

A

Separation-based analysis

30
Q

Dynamic Light Scattering vs Transmission Electron Microscopy

Which one is faster?

A

DLS

31
Q

Dynamic Light Scattering vs Transmission Electron Microscopy

Which one is slower?

A

TEM

32
Q

Dynamic Light Scattering vs Transmission Electron Microscopy

Which one provides more accurate size?

A

TEM

33
Q

Dynamic Light Scattering vs Transmission Electron Microscopy

Which one is hydrodynamic?

A

DLS

34
Q

Pros/Cons of Stable nanomedicines?

A

Stable, easy to manufacture

Useless

35
Q

Pros/Cons of Metastable nanomedicines?

A

Useful

Expensive to make + store

36
Q

What is Q1 equivalency?

A

Same material

37
Q

What is Q2 equivalency?

A

Same concentration

38
Q

What is Q3 equivalency?

A

Particle size (or other physiochemical properties)

Pharmaceutics (30 decks)

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