Block 4 Flashcards
Novel Injectables
For IM injections, how much can you inject?
2-5mL, larger than subQ inj
Novel Injectables
For SubQ injection, how much can you inject?
1-2mL, smaller than IM inj
Novel Injectables
IM vs SubQ, which one allows mild irritants to be used?
IM
Novel Injectables
IM vs SubQ, which one only allows non-irritating substances?
SubQ
Novel Injectables
Why does IM inj allow mild irritants?
Muscles are more vascular and have fewer sensory nerves
Novel Injectables
What is the primary route of delivery for subQ inj?
Protein-based drugs
Which novel inj solution allows controlled release to take place for months - year?
Polymer-based in situ forming systems
Which novel inj solution has the shortest controlled release profile?
Oil-based solution
What is the rate limiting step in oil-based novel injections?
Dissolution
What is an iontophoresis?
Migration of ionic drug into tissue by electric current
What are some advantages of iontophoresis?
- Controlled delivery rate
- Eliminates GI issues
- Avoid risk of infection, inflammation, etc
- Enhanced pt compliance
What are some disadvantages of iontophoresis?
Irritation at high current densities
What is a phonophoresis?
Transport of drug thru tissue via ultrasound
With phonophoresis, what is the drug usually mixed with?
Coupling agent (gel, cream, etc)
Which layer of the skin is involved with phonophoresis?
Stratum corneum
Explain the caviation MOA of phonophoresis
Formation of small air bubbles leading to disordering of lipid bilayer forming a channel
Explain the microstreaming MOA of phonophoresis
Efficient mixing by inducing eddies, which enhances dissolution
Explain the heat generation MOA of phonophoresis
Converts ultrasound energy to heat energy
“Pharmacy on a Chip” what is this?
Device designed to deliver 200 months (16yrs) worth of progestin for birth control
“Accordion Pill” what is this?
Biodegradable polymeric film that is folded to an accordion shape stuffed into a capsule
Retains in stomach for 8 to 12 hours (up to 550mg)
“Sushi Implant” what is this?
Treats T1DM, artificial pancreas
What are the components of therapeutic nanoparticles?
- Targeting mechanism
- Destructive mechanism
- Molecular packaging
What is the size of a nanoparticle?
10^-9 m = 1nm
In a liposome, what are hydrophilic and hydrophobic drug loaded at?
Hydrophilic - core
Hydrophobic - lipid bilayer
MOA Doxil (Doxorubicin)?
Topoisomerase II inhibitor
What is included in a batch analysis size technique?
DLS + SLS
DLS + SLS is found in what sizing technique?
Batch analysis
What is included in a separation-based analysis for sizing techniques?
FFF, LC, and AUC
FFF, LC, and AUC is found in what sizing technique?
Separation-based analysis
Dynamic Light Scattering vs Transmission Electron Microscopy
Which one is faster?
DLS
Dynamic Light Scattering vs Transmission Electron Microscopy
Which one is slower?
TEM
Dynamic Light Scattering vs Transmission Electron Microscopy
Which one provides more accurate size?
TEM
Dynamic Light Scattering vs Transmission Electron Microscopy
Which one is hydrodynamic?
DLS
Pros/Cons of Stable nanomedicines?
Stable, easy to manufacture
Useless
Pros/Cons of Metastable nanomedicines?
Useful
Expensive to make + store
What is Q1 equivalency?
Same material
What is Q2 equivalency?
Same concentration
What is Q3 equivalency?
Particle size (or other physiochemical properties)
