Ear Drug Delivery Flashcards
What is found in the OUTER EAR?
Pinna to Tympanic membrane
What is found in the MIDDLE EAR?
Auditory ossicles, Eustachian tube, and round/oval window membrane
What is found in the INNER EAR?
Vestibular portion, Cochlea, and auditory nerve
What is the purpose of the oval window?
Leads to the vestibule; amplification of sound
What is the purpose of the round window?
Its vibrations allow fluid in the cochlea to move
Besides for balance, what else does the vestibular system do?
Sends signals that control eye movement and keeps the muscles of the eye upright
What is the most common dosage form for otic disorders?
Solutions
What are the advantages of using a solution?
Convenient
What are the disadvantages of using a solution?
Short residence time
What are the disadvantages of using a ointment?
- Could block ear canal
2. Could be painful to apply
What are the otic dosage forms?
- Solution
- Suspension
- Ointment
- Powders
Muramidase, a component of mucosal glands, does what?
A lysozyme that lyses G+ bacteria
What is the most common infection in children?
Otitis Media
Do antibiotics have any effect on the clearance of the fluid?
Nope
What is the main site of drug delivery from middle to inner ear?
Round window membrane