Ear Drug Delivery Flashcards

1
Q

What is found in the OUTER EAR?

A

Pinna to Tympanic membrane

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2
Q

What is found in the MIDDLE EAR?

A

Auditory ossicles, Eustachian tube, and round/oval window membrane

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3
Q

What is found in the INNER EAR?

A

Vestibular portion, Cochlea, and auditory nerve

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4
Q

What is the purpose of the oval window?

A

Leads to the vestibule; amplification of sound

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5
Q

What is the purpose of the round window?

A

Its vibrations allow fluid in the cochlea to move

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6
Q

Besides for balance, what else does the vestibular system do?

A

Sends signals that control eye movement and keeps the muscles of the eye upright

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7
Q

What is the most common dosage form for otic disorders?

A

Solutions

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8
Q

What are the advantages of using a solution?

A

Convenient

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9
Q

What are the disadvantages of using a solution?

A

Short residence time

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10
Q

What are the disadvantages of using a ointment?

A
  1. Could block ear canal

2. Could be painful to apply

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11
Q

What are the otic dosage forms?

A
  1. Solution
  2. Suspension
  3. Ointment
  4. Powders
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12
Q

Muramidase, a component of mucosal glands, does what?

A

A lysozyme that lyses G+ bacteria

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13
Q

What is the most common infection in children?

A

Otitis Media

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14
Q

Do antibiotics have any effect on the clearance of the fluid?

A

Nope

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15
Q

What is the main site of drug delivery from middle to inner ear?

A

Round window membrane

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16
Q

What are some middle ear drug application issues?

A
  1. Anatomic obstruction of round window membrane

2. Drug loss via Eustachian tube

17
Q

What are some issues w/ osmotic pumps to deliver medicine to inner ear?

A
  1. Inability to deliver varying dosages
  2. Inability to start and stop w/o removing system
  3. Limited duration of drug delivery