Physiochemical Properties of Solutions

Question 1

Which type of solutions are unstable?

Answer 1

Supersaturated

Question 2

The solubility of gases in liquids ________ with increasing temperature

Answer 2

decrease

Question 3

The solubility of gases in liquids decrease with _________ temperature

Answer 3

increasing

Question 4

Why does increasing temperature decrease solubility in gases?

Answer 4

Provides energy that overcomes the attractive forces between the gas and solvent molecules, thereby allowing the gas to escape

Question 5

When does Henry’s Law not apply?

Answer 5

Gases that react with solvents

Question 6

What is Henry’s Law?

Answer 6

At a constant temperature, the solubility of a gas (Cg) in a solvent increases as the partial pressure (Pg) of the gas above the solution increases.

Question 7

What does the dosage form contain?

Answer 7

API + Excipient

Question 8

Which are more water soluble, monovalent or multivalent molecules?

Answer 8

Monovalent

Question 9

What is the relation between molecular weight and water solubility?

Answer 9

Increase weight = decreased solubilty

Question 10

What is the relation between branching and water solubility?

Answer 10

More branches = increased solubilty

Question 11

What is the relation between polar groups and water solubility?

Answer 11

More polar groups = increased solubility

Question 12

What is the relation between halogens and water solubility?

Answer 12

More halogens = decreased solubility

Question 13

What is Lipinski’s Rule of Five?

Answer 13

Compound should be:
<500 molecular weight
LogP = <5
H Bond Donors <5
H Bond Acceptor <10