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Pharmaceutics > Suspension > Flashcards

Suspension Flashcards

1
Q

Suspensions have _____ dissolution/absorption than tablets

A

faster

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2
Q

Suspensions have _______ dissolution/absorption than solutions

A

slower

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3
Q

What are the three kinds of delivery routes in suspensions?

A
  1. Oral
  2. Externally applied
  3. Parenteral
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4
Q

What are the two classifications of suspensions?

A
  1. Colloidal

2. Coarse

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5
Q

What are the particle sizes in colloidal suspensions?

A

<1 micron

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6
Q

Which classification of suspensions are always treated as suspensions?

A

Coarse

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7
Q

Which classification of suspensions are treated as either suspensions or solution depending on the case?

A

Colloidal

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8
Q

What are the particle sizes in coarse suspensions?

A

> 1 micron

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9
Q

Which classification of suspensions settle under gravity?

A

Coarse

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10
Q

Which classification of suspensions typically do not settle?

A

Colloidal

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11
Q

A good pharmaceutical suspension has _____ sedimentation rate

A

slow

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12
Q

Sedimentation rate is derived from ideal situations where particles are _____ and ____

A

uniform, spherical

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13
Q

Sedimentation rate is derived from ideal situations where suspension is _______

A

dilute

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14
Q

Sedimentation rate is derived from ideal situations where no _______ during particle settling

A

turbulence

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15
Q

Sedimentation rate is derived from ideal situations where no particles ________ with each other

A

collide

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16
Q

Sedimentation rate is derived from ideal situations where no _____ and _____ interactions between particles and medium

A

chemical, physical

17
Q

What is Stokes equation?

A

Rate of sedimentation =

d^2(particle density - medium density) * gravitation constant /(18 * viscosity of medium)

18
Q

Stokes equation does / does not apply directly to pharmaceutical preparations

A

does not

19
Q

T / F Suspensions will not always settle over time

A

False, eventually settle

20
Q

What happens if density of medium is greater than density of particles?

A

Particles float to surface

21
Q

Why is having particles floating to the surface a bad thing?

A

Although there is not settling, it makes dosing difficult

22
Q

What happens if density of particles is greater than density of medium?

A

Particles settle

23
Q

What happens if density of particles is MUCH greater than density of medium? What the problem with it?

A

Particles settle very fast

May be difficult to dose accurately

24
Q

Why is having particle sizes too small a problem?

A

Settles slowly, but forms hard cake

25
Q

Why is having particle sizes too large a problem?

A

Will settle fast, but will be easy to re-disperse

26
Q

Vehicle vs particle, which is easier to adjust?

A

Particles

27
Q

How easy is ti to re- distribute hard cakes?

A

It’s not easy, it is to be avoided

28
Q

What is flocculation?

A

The process by which particles settle fast in a very loose/easy to redisperse mass

29
Q

What can you add to promote flocculation?

A
  1. Clays in oral suspension
  2. pH adjustment / electrolytes
  3. Surfactants
30
Q

How does adding sufactants promote flocculation?

A

Wet particle surfaces + prevents them from sticking to each other

31
Q

How does adjusting pH and electrolytes promote flocculation?

A

Promotes ionic interaction to form a structure

32
Q

What kind of tension does surfactants bring to the lipophilic particle and the hydrophilic medium?

A

Interfacial tension

33
Q

How much wetting agent should you use when preparing suspensions? Why?

A

As little as possible

Too much causes foaming, bad taste, dissolution of drug

34
Q

In general, drugs are ____ stable in liquid than solid form

A

less

Pharmaceutics (30 decks)

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