Nasal Drug Delivery Flashcards
Do inhalations avoid first-pass metabolism?
Yes
How fast do inhalations work?
Rapid onset
Inhalation have (local/systemic) drug delivery
Both
What are the disadvantages of inhalations?
If you have a cold/allergy, you could alter bioavailability
The nasal cavity has a high surface area due to what?
3 bony structures called turbinates
What kind of absorption is it thru olfactory sensory neurons?
Transneuronal absorption
Where does most of the absorptiona take place via inhalation?
Respiratory epithelium lines
What are the 3 main possible ways medications are absorbed via olfactory region?
- Intracellular
- Paracellular
- Transceullar
What are the 3 possible distribution patterns via olfactory region?
- General circulation
- Lymph nodes
- Brain stem
The enzymatic barrier of the nasal passage creates what kind of effect?
Pseudo-first pass effect
What enzyme metabolizes the inhaled pollutants?
P-450
When you have acute rhinitis or sinusitis, your nasal passage becomes more (acidic/basic)
basic
What is the pH range of nasal solutions?
5.5 to 7.5
What is the particle size of effect nasal solutions?
3 to 7 microns
What is wrong with small particles (<3 microns)?
Lost in exhaled breaths
