Tranexamic Acid (TXA)

Question 1

Tranexamic Acid Class

Answer 1

Anti-fibrinolytic

Question 2

Tranexamic Acid Description

Answer 2

An anti-fibrinolytic which reduces the breakdown of blood clots

Question 3

Tranexamic Acid Presentation

Answer 3

Ampoule 500mg in 5ml

Question 4

Tranexamic Acid Administration

Answer 4

Intravenous Infusion (IV)
Intraossseous (IO)

Question 5

Tranexamic Acid Indications

Answer 5

Suspected significant internal or external haemorrhage associated with trauma.
Postpartum Haemorrhage

Question 6

Tranexamic Acid Contra-indications

Answer 6

Hypersensitivity to the active substance or to any of its excipients
Acute venous or arterial thrombosis
History of convulsions
Known Severe Renal Impairment

Question 7

Tranexamic Acid Dose

Answer 7

Adult: 1g IV Infusion in 100ml NaCl

Paed: Not Indicated

Question 8

Tranexamic Acid Pharmacology

Answer 8

Tranexamic acid exerts an anti-haemorrhagic activity by inhibiting the activation of plasminogen to plasmin, by binding to specific sites of plasminogen and plasmin, a molecule responsible for the degradation of fibrin, a protien that forms the framework of blood clots

Question 9

Tranexamic Acid Side Effects

Answer 9

Diarrhoea
Nausea and Vomiting

Uncommon:
Visual Disturbance
Impaired coloured vision
Dizziness
Headache

Question 10

Tranexamic Acid Additional Info

Answer 10

Caution with Head Injury