Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Fall-Foundational Sciences Year 1 > Tissue Types/Cell Coordination > Flashcards

Tissue Types/Cell Coordination Flashcards

1
Q

Tissue

A

group of similar cells with common function + nonliving macromoles and fluid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Basic types of tissues

A

epithelial
muscle
nervous
connective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Epithelial

function

A

secretion
absorption
lining
covering
protection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

connective

function

A

connection
integration
support
exchange
store
defense

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Muscle

function

A

contraction
movement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Nervous

A

recieve/transmit/integrate info

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

goals of tissues

A

communication
physical support
cohesiveness and exclusivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

cell junctions

definition

A

specializations of cell surface that connect adjacent cells to each other or part of ECM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

cell junctions

function

A

tissue continuity
cohesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

cell junctions

components

A

transmembrane protein (TMP)
connect to attachment protein
connect to cytoskeletal filament

attachment proteins are peripheral
cytoskeletal is actin or intermed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Types of Cell Junctions

A

occluding/tight
anchoring/adhering
communicating/gap

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Occluding Junctions

A

seal that encircles a cell/stitches
band of interlocking branching/reticulating sealing strands

only in epithelial cells at luminal end of lateral domain

shows as fusion of adjacent cells TEM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Occluding Junctions

functions

A

regulate paracellular permeability
reg which lumen contents get b/t cells
block pathogens
signaling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Occluding Junctions

structure

A

TMP: claudins (required for correct formation, water) and occludins (stability)
AP: ZO proteins
CC: actin filaments

AP= attachment protein
CC= cytoskeletal component

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

hereditary claudin-14

A

mutation that inc permeability of water in hearing receptors (organ of corti) so no action potentials = deafness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Anchoring Junctions

A

@ lateral or basal domain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Anchoring Junction

functions

A

link cytoskeletons of adjacent cells
connect cytoskeleton to ECM fibers
mechanotransduction for morphogenesis/cell differentiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Subtypes of anchoring junctions

A

adhesion belt
desmosomes
hemidesmosomes
focal adhesions

19
Q

Adhesion belts

A

@ lateral domain
function: lateral adhesion to adj cells, resist mechanical stress

20
Q

Adhesion belt

structure

A

TMP: cadherins
AP: catenins, vinculin, alpha-actinin
CC: actin filaments

21
Q

Desmosomes

A

@ random on lateral domain
basal to adhesion belts

22
Q

Desmosomes

function

A

lateral adhesion to adj cells
resist mechanical stress
tissue morphogenesis/cell differentiation

23
Q

Desmosomes

structure

A

TMP: cadherins
AP: desmoplakin, catenin
CC: intermediate filaments

24
Q

Hemidesmosomes

A

@ basal domain
esp epithelia of cornea, oral mucosa, esophagus, vagina

25
Q

Hemidesmosomes

functions

A

anchor basal domain to ECM
resist abrasion or shearing

26
Q

Hemidesmosomes

structures

A

TMP: integrins, type XVII collagen (within cell)
»laminins, type IV collagen (ECM/basement)
AP: desmoplakin-like proteins
CC: intermediate filaments

TMP no counterpart so half desmosome

27
Q

Focal adhesions

A

@ basal domain

28
Q

Focal adhesions

functions

A

anchor basal domain to basement membrane and ECM
sense/transmit signal from ECM into cell
regulate cell migration

29
Q

Focal adhesions

structure

A

TMP: integrins (in cell)&raquo_space; fibronectin, laminins (in ECM)
AP: talin, vinculin, alpha-actinin
CC: actin filaments

30
Q

Pemphigus vulgaris

A

clinical relevance of anchoring junctions
antibodies vs desmoglein 1 and 3 (TMP desmo)&raquo_space; connections disrupted = severe blistering of skin and mucous membranes

basal domain stays attached, fluid b/t basal and apical

31
Q

Bullous pemphigoid

A

Clinical for anchoring junctions
autoimmune disease antibodies vs type XVII collagen (TMP hemi)&raquo_space; disrupt connections to basement membrane = large blisters under epidermis

cell stays together but separates from basement membrane

32
Q

Communicating Junctions

A

broad pores/channels align to form conduits spanning cell membranes

@ lateral domain (embryos, muscle, neurons esp)

33
Q

Communicating Junctions

functions

A

form channels b/t cytoplasm of adj cells
direct exchange fluids/metabolites/signals
coordinate activity across entire tissue

34
Q

Communicating Junctions

structure

A

TMP: 6 connexins in circle = connexon
AP: none
CC: none

35
Q

Junction complexes

A

@ simple epithelial
function: triple barrier

36
Q

Junction complex

structure

A

apical»basal
1.occulding tight junction
2.adhesion belt
3.ring of small desmosomes “belt”

ducts and capillaries are one cell layer thick “simple” so need extra pr

37
Q

domains w/ cell junctions

A

lateral bc cell to cell
basal bc cell to basement mem

apical domain none

38
Q

Structure of Gap/Comm Junctions

simplified

A

only transmembrane proteins

39
Q

Structure of occluding and anchoring junctions

simplified

A

All 3 components
TMP + AP + CC

40
Q

junctions with ‘adhesion’

anchoring

A

connect to actin filaments
AP: alpha actin, vinculin

41
Q

junctions with ‘desmo’

anchoring

A

connect with intermediate filaments
AP: desmoplakin

42
Q

lateral junctions

anchoring

A

cadherin TMP
catenin AP

43
Q

basal junction

anchoring

A

integrin TMP
plus type XVII collagen in hemidesmosomes

44
Q

TMPs in basal domain

A

connect to laminins + fiber

hemidesmosomes fiber = type IV collagen
focal fiber = fibronectin

Fall-Foundational Sciences Year 1 (33 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions