Ticagrelor Flashcards
1
Q
Drug class
A
Antiplatelet
2
Q
Pharmacology
A
Is a reversibly binding, direct-acting adenosine diphosphate (ADP) receptor antagonist that inhibits platelet activation & aggregation
3
Q
Metabolism
A
Hepatic
4
Q
Indications
A
• Pts with STEMI (as defined by relevant QAS coronary artery reperfusion checklist) who have been accepted for pCI (as an adjunct medication to aspirin & heparin AND the receiving cardiologist is requesting administration
5
Q
Contraindications
A
- Allergy and/or adverse drug reaction
- Current use of ticagrelor or clopidogrel
- <18yrs
- Active bleeding (exclud. menses)
- Hx intercranial haemorrhage
- Hx hepatic impairment
6
Q
Precautions
A
- Concomitant meds known to induce bradycardia (e.g B-blockers, CCBs, digoxin)
- Symptomatic bradycardia (HR<60)
7
Q
Side effects
A
- Haemorrhage
* Bradycardia
8
Q
Presentation
A
- 90mg tablet
* 90mg ODT
9
Q
Route
Onset
Duration
A
PO
~30mins
7days (antiplatelet)
10
Q
Adult dosages
A
Pts with STEMI, accepted for pPCI (as adjunct to aspirin & heparin) AND cardiologist requests admin
• PO ≥18yrs 180mg
