Clopidogrel

Question 1

Drug class

Answer 1

Antiplatelet

Question 2

Pharmacology

Answer 2

Specific & potent platelet aggregation inhibitor.
Selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor, thereby inhibiting platelet aggregation.

Question 3

Metabolism

Answer 3

Hepatic metabolism with near equal amounts excreted in urine & faeces

Question 4

Indications

Answer 4

For pts with STEMI (as defined by CPP); AND
• who have been accepted for pPCI (as an adjunct medication to aspirin & heparin) & the receiving cardiologist is requesting administration; OR
• who have received tenecteplase (& have been administered aspirin & enoxaparin

Question 5

Contraindications

Answer 5

• Allergy and/or adverse drug reaction
• Pts contraindicated for pre-hosp fibrinolysis
• Current clopidogrel OR ticragelor therapy
• Pt <18yrs
• Active bleeding (excluding menses)
• Prior intracranial haemorrhage

Question 6

Precautions

Answer 6

Severe renal impairment

Question 7

Side effects

Answer 7

Haemorrhage

Question 8

Presentation

Answer 8

Pink 75mg tablet

Question 9

Onset

Duration

Answer 9

~30mins

7-10 days (antiplatelet)

Question 10

Routes of Admin

Answer 10

Per oral (PO)

Question 11

Adult Dosages

Answer 11

For pts with STEMI (as per CARC) who have been accepted for pPCI (as an adjunct med to aspirin & heparin) & the receiving cardiologist is requesting administration
▪︎ PO ≥ 18yrs 600mg
Swallowed with small amount of water

For pts with STEMI (as per CARC) who have received tenecteplase (& have been administered aspirin & enoxaparin
▪︎PO ≥ 18yrs 300mg
Swallowed with small amount of water