Aspirin

Question 1

Drug class

Answer 1

Antiplatelet

Question 2

Pharmacology

Answer 2

Inhibits platelet aggregation by irreversibly inhibiting cycli-oxygenase, reducing the synthesis of thomboxane A2 (an inducer of platelet aggregation) for the life of the platelet. This forms the basis of preventing platelets from aggregating to exposed collagen fibres at the site of vascular injury.

Question 3

Metabolism

Answer 3

Converted to salicylic acid in many tissues, but primarily the GI mucosa & liver. Excreted by the kidneys.

Question 4

Indications

Answer 4

• Suspected ACS

* Acute cardiogenic pulmonary oedema

Question 5

Contraindications

Answer 5

• Allergy and/or adverse drug reactions to aspirin OR any NSAID
• CP associated with psychostimulant OD
• Bleeding or clotting disorders
• Current GI OR peptic ulcers
• Pts < 18yrs

Question 6

Precautions

Answer 6

• Possible aortic aneurysm or any other condition requiring surgery
• Pregnancy
• Hx GI bleeding or peptic ulcers
• Concurrent anticoagulant therapy

Question 7

Side effects

Answer 7

• Epigastric pain/discomfort
• Nausea and/or vomiting
• Gastritis
• GI Bleeding
• NSAID induced bronchospasm

Question 8

Presentation

Answer 8

Tablet 300mg

Question 9

Onset

Duration

Answer 9

~ 10mins

~ 1 week

Question 10

Adult dosage

Answer 10

PO 300mg

* chewed & swallowed with small sip of water