Hydroxocabalamin Flashcards
1
Q
Drug class
A
Antidote
2
Q
Pharmacology
A
An injectable form of V-B12 which is an antidote for cyanide toxicity. It binds with circulating & cellular cyanide to form cyanocobalamin which is then excreted in urine
3
Q
Metabolism
A
Excreted by kidneys
4
Q
Indications
A
Life-threatening cyanide toxicity (e.g shock, resp failure, seizure, ALOC or myocardial ischaemia
5
Q
Contraindications
A
Allergy and/or adverse drug reactions
6
Q
Precautions
A
- Hypertension (substantial > occur with admin)
* Pregnancy (ONLY use if benefits justifies potential risk to foetus)
7
Q
Side effects
A
- Anaphylaxis
- Chromaturia
- Erythema
- Rash (acne like)
- Hypertension
- Renal failure
- Headache
- Nausea and/vomiting
- Pain @ inj site
8
Q
Presentation
A
5g vial
9
Q
Onset
Duration
A
IV
Immediate
Several days
10
Q
Routes of administration
A
IV Infusion
11
Q
Adult dosages
A
IV INF
5g over 15min
12
Q
Special notes
A
• CONSULT - nonife threatening toxicity e.g headache, confusion, vomiting, dyspnoea, chest tightness
