Glycerol Trinitrate Flashcards
1
Q
Drug class
A
Vasodilator
2
Q
Pharmacology
A
A potent vasodilator that decreases preload by increasing venous capacity, pooling venous blood in the peripheral veins, reducing ventricular filling pressure & decreasing arterial blood pressure (after load). This cascade causes vasodilation in coronary arteries that are in spasm & may assist the redistribution of blood flow along the collateral channels in the heart
3
Q
Metabolism
A
Rapidly absorbed & metabolised by the liver
4
Q
Indications
A
- Suspected ACS (with pain)
- Acute cardiogenic pulmonary oedema
- Autonomic dysreflexia (systolic ≥160mmHg)
- Irukanji syndrome (systolic ≥160mmHg)
5
Q
Contraindications
A
• Allergy and/or adverse drug reaction • HR <50 OR >150 bpm • Systolic BP <100mmHg • Acute CVA • Head trauma • Phosphodiesterase 5 inhibitor meds ▪︎Sildenafil or verdafil in prev. 24hrs ▪︎ Tadalafil in prev. 48hrs
6
Q
Precautions
A
- Suspected inferior AMI
- Cerebral vascular disease
- Risk of hypotension and/or syncope
- Intoxication
- Phosphodiesterase 5 inhibitor meds in previous 4 days
7
Q
Side effects
A
- Dizziness
- Hypotension
- Syncope
- Reflex tachycardia
- Vascular headaches
8
Q
Presentation
A
SUBLING, 400mcg/dose (200 doses)
9
Q
Onset
Duration
A
<2min
20-30min
10
Q
Adult Dosages
A
- Suspected ACS (with pain);
- Acute cardiogenic pulmonary oedema;
- Autonomic dysreflexia
- Irukanji syndrome
SUBLING, 400mcg, repeated @ 5min, no max dose
11
Q
Paediatric dosages
A
- Autonomic dysreflexia;
- Irukanji syndrome
CONSULT
