Naloxone Flashcards
1
Q
Drug class
A
Opioid antagonist
2
Q
Pharmacology
A
Naloxone competes for the same receptor sites as opioid drugs. It antagonises opiod effects to prevent or reverse respiratory depression, sedation and hypotension.
3
Q
Metabolism
A
Hepatic
4
Q
Indications
A
Respiratory depression (secondary to the administration of narcotic drugs)
5
Q
Contraindications
A
- Allergy and/or adverse drug reaction
* Newly born
6
Q
Precautions
A
Cardiac disease
7
Q
Side effects
A
- Narcotic reversal can cause combativeness, vomiting, sweating, tachycardia & hypertension
- Acute withdrawal convulsions in chronic user
- Pulmonary oedema
8
Q
Presentation
A
400mcg/ml amp
9
Q
Route
Onset
Duration
A
IM
3-5min
~60min
10
Q
Special notes
A
- Adequate oxygenation/ventilation prior to admin
- Renarcotisation possible
- May unmask potential unwanted side effects in poly-pharm OD
- DO NOT admin to newborn as it may lead to acute withdrawal and seizures
11
Q
Adult dosages
A
Respiratory depression (secondary to admin of narcotic drugs)
IM 1.6mg, single dose only
12
Q
Paediatric dosages
A
Respiratory depression (secondary to admin of narcotic drugs)
IM 20mcg/kg, single dose only, not to exceed 800mcg
