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BECOM II EXAM IV > Thyroid hormones > Flashcards

Thyroid hormones Flashcards

1
Q

T/F the thyroid gland is highly vascularized

A

T

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2
Q

what cells secrete calcitonin

A

parafollicular C cells

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3
Q

what is most abundantly secreted from the thyroid

A

T4

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4
Q

what is the most active product secreted from the thyroid

A

T3

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5
Q

what AA primarily constsitutes thryoglobin

A

tyrosine

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6
Q

what is the thyroid gland cancer biomarker

A

Tg

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7
Q

what symporter concentrates iodide in the thyroid

A

sodium-iodide symporter

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8
Q

what other things can NIS transport

A

bromide, thiocyanate, perchlorate

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9
Q

what is technetium isotope used for

A

imaging of thyroid

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10
Q

at the apical end, what transports iodide into the follicle for iodination of tg precurser

A

pendrin

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11
Q

what does lack of pendrin cause

A

congenital hypothyroidism

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12
Q

antibodies to NIS are seen in

A

hashimoto thyroiditis

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13
Q

where does iodination of Tg occue

A

in the follicles extracellulary

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14
Q

what enzyme oxidizes the iodide to iodine

A

TPO

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15
Q

TPO links to I to tyrosine residues within

A

Tg

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16
Q

TPO is stimulated by

A

TSH, hCG

17
Q

In patients with congenital deficiency of iodotyrosine deiodinase what is found in the urine

A

MIT, DIT

18
Q

What lets the iodide in the cell and what moves the iodide out for coupling

A

NIS and pendrin

19
Q

What carries thyroid hormones

A

TBG, transthyretin, or albumin

20
Q

What kind of recceptor is SDHR

A

GPC, cAMP

21
Q

Excess TSH leads to a

A

Goiter

22
Q

What is the effect of dvelopment and dgorwth on excess T3

A

Causes expression of GH, IGF1, resulting in short stature and mental reetardation

23
Q

Graves’ disease has high _____ and low

A

T4; low TSH

24
Q

What would have the symptoms of heat intolerance, sweating, weight loss, femoris, SOB, amenorrhea, fatigue, water hammer pulse

A

Hyperthyroidism

25
Q

Cold intolerance

A

Hypothyroidism

BECOM II EXAM IV (19 decks)

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