Thyroid hormones Flashcards
T/F the thyroid gland is highly vascularized
T
what cells secrete calcitonin
parafollicular C cells
what is most abundantly secreted from the thyroid
T4
what is the most active product secreted from the thyroid
T3
what AA primarily constsitutes thryoglobin
tyrosine
what is the thyroid gland cancer biomarker
Tg
what symporter concentrates iodide in the thyroid
sodium-iodide symporter
what other things can NIS transport
bromide, thiocyanate, perchlorate
what is technetium isotope used for
imaging of thyroid
at the apical end, what transports iodide into the follicle for iodination of tg precurser
pendrin
what does lack of pendrin cause
congenital hypothyroidism
antibodies to NIS are seen in
hashimoto thyroiditis
where does iodination of Tg occue
in the follicles extracellulary
what enzyme oxidizes the iodide to iodine
TPO
TPO links to I to tyrosine residues within
Tg
TPO is stimulated by
TSH, hCG
In patients with congenital deficiency of iodotyrosine deiodinase what is found in the urine
MIT, DIT
What lets the iodide in the cell and what moves the iodide out for coupling
NIS and pendrin
What carries thyroid hormones
TBG, transthyretin, or albumin
What kind of recceptor is SDHR
GPC, cAMP
Excess TSH leads to a
Goiter
What is the effect of dvelopment and dgorwth on excess T3
Causes expression of GH, IGF1, resulting in short stature and mental reetardation
Graves’ disease has high _____ and low
T4; low TSH
What would have the symptoms of heat intolerance, sweating, weight loss, femoris, SOB, amenorrhea, fatigue, water hammer pulse
Hyperthyroidism
