Pancrease Flashcards
Pancreatic B cells produce
Amylin and insulin
Pancreatic alpha cells secrete
Glucagon
Pancreatic D cells secrete
Somatostatin
Pancreatic F cells secrete
PP
What does amylin do
Controls emptying of stomach, saiety, weight loss, inhibits glucagon
What does pancreatic somatostatin do
Inhibits segregation of pancreatic hormones (esp insulin), decreases GI motility, stim by glucose and AA
What is the bio marker for pancreatic adenocarcinoma
PP
What is used as the indicator for insulin secretion
C-peptide
What kind of receptors inhibit insulin
Alpha adreneregenic
How does parasymmpathetics increase insulin
Arch Stimulates PLC which releases Calcium
What is sulfonylurea used for
Type II diabetes, blocks the ATP dependent K leak channel
What transporter does glucose use to enter pancreatic B cells
GLT2
What does incretin come From and what does it do
GLP-1, GIP, CCK; primes pancreas for insulin release
What does meformin do
Stimulates GIP, used to treat type II diabetes
How does dipeptidyl peptides even IV inhibitors work
Increase the GLP1 for a longer time, improves glucose tolerance
What does PTP do
Terminates signal of insulin receptor
What is the effect of insulin on lipoprotein lipase and FA synthase
Increases both
Insulin and light exercise increase the expression of
GLUT-4
Chronic stress and intense exercise induces
Hyperglycemia
GH, cortisol, and glucagon are all
Ketogenic
What are the stimulators of glucagon
Hypoglycemia, AA, NE, EPI
Glucagon is inhibited by
Insulin, somatostatin, FA
Glucagon uses what pathway
G protein
What is the effect of hyperkalemia on insulin release
Increases insulin release
