Thrush- Tumor Immunology Flashcards
cancer cells are ____ self cells. they may express diff markers and have abnormal growth control. (lack of apoptosis, and p53 mutations)
altered
what is a malignant cancer cell? what is metastasis
when cancer cells invade other cells and go where they are not supposed to be
what are the different mutations
- chemical carcinogens; nitrates, asbestos, nicotine/tar
- physical carcinogens; UV light (sun), radiation
- viruses; Human T cell lymphotrophic virus 1 (HTLV-1), Epstein Barr virus (EBV), hepatitis virus, human papillomavirus (HPV)
Because of the mutations, cancers are:
- complex genetic disease
- heterogenous; constant changes and evasion of host control
- often has lack of antigenicity; derived from host
- metastatic; able to move form one location to another
how do you increase gene expression
move regulatory gene next to a diff promoter region.
____ gets expressed in certain situations and not. if moves to a gene that is always turned on, the gene constantly gets turned on, B cell proliferates and you get burst lymphoma (8–> 14). If you move cyme next to T cell receptor enhancer, it won’t be a problem. (usually silenced)
c-myc
colon cancer is due to_____mutations in a stepwise fashion. You make a mutation in a tumor suppressor gene, then the protein that was encoded by the gene is not working well then you get mutation in oncogene and other TSG’s until you get to the stage of metastatic cancer.
multiple
There is a variable immune response, Since ____ derived (self), tumors may not be recognized as foreign = no immune response. Also if immunosuppressed, increased incidence of cancer formation. Some tumors do have significant antigenic determinants and can be recognized as “altered.” –>melanomas (uv light), or virally induced tumors. Tumor infiltrating lymphocytes are usually suppressed
host
what are tumor antigens
Ag expressed only by the tumor, therefore they are abnormal/foreign antigens. Reality is there aren’t a lot of these out there.
what are tumor associated antigens
not unique to tumor cells but there is something abnormal about them. Normal proteins, but not normal proteins for an adult. (expressing moleucules at abnormal time in stage of development). may be proteins expressed at low levels in normal cells but much higher on the cancer cell.
what are the two categories of tumor antigens
- tumor specific
2. tumor associated antigens
what are oncofetal antigens
normal proteins exp during fetal dev but during cancer formation they get formed again. CEA is found in some colon cancers and these levels of marker proteins could be used to measure cancer burden
what are markers of oncofetal antigens
- Carcinoembryonic antigen (CEA): found in some colon cancers and also can be used to measure cancer burden.
- Alpha fetoprotein (AFP): increased in hepatitis or pregnancy. It can also mean they have cancer; found in patients with liver and germ cell tumors.
___ antigens; you can have viral proteins by expressed and presented with MHC class I.
viral;
what are the oncoviral proteins associated with?
HPV type 16, E6, and E7 proteins
Nautre of antigen: viral transforming gene products.
Tumor type: cervical carcinoma