Parsa - Hemodynamic Disorders Flashcards
What are the cellular components that are most frequently damaged by injurious stimuli?
- mitochondria
- cell membranes
- the machinery of protein synthesis and packaging
- DNA in nuclei
What are the components that contribute to thrombosis
- sub endothelial collagen
- platelets
- coagulation system
what is endothelial injury due to
hypercholesterolemia or
- inflammation bc if exposure of sub endothelial collagen
- platelet adhesion and aggregation at the site of injury to form a primary platelet plug
what are the lab findings of endothelial injury
- inflammation: c -reactive protein
- infection: sepsis
- massive tissue destruction:
what does platelet adhesion and aggregation depend on
- von wildebrand factor that functions as an adhesion bridge between sub endothelial collagen and the glycoprotein lb platelet receptor
- fibrinogen bridging Gplb-illa receptors on diff platelets accomplishing aggregation.
What is the clinical assessment of platelets
- spontaneous mucosal bleeding.
2. petechiae and ecchymoses
how is clotting initiated in the lab via the intrinsic way?
- adding phospholipids, calcium, and either a negative charged substance such as glass beads
* factor 12
how is clotting initiated in the lab via the extrinsic pathway
via tissue factor, a membrane bound glycoprotein that is expressed by sub endothelial cells. Activates factor VII
how is clotting initiated in the lab via the extrinsic pathway
via tissue factor, a membrane bound glycoprotein that is expressed by sub endothelial cells.
Which assay assesses the function of the protein in the extrinsic pathway
PT (Prothrombin time) *factor 7
Which assay assesses the function of the protein in the extrinsic pathway
PT (Prothrombin time)
Among the coagulation factor which is the most important?
thrombin
Among the coagulation factor which is the most important?
thromin
What are the lab and clinical assessment for the the coagulation system
- severe liver disease inteferes with production of fibrinogen factors: 2, 5, 7-11
- patients on anticoagulant hterapy
- patients with vitamin K deficiency
What are factor deficiencies for the coagulation system
- hemophilia A: factor 7 deficiency
2. Hemophilia B: factor 9 deficiency