Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

principles of disease > thrombosis > Flashcards

thrombosis Flashcards

1
Q

what is thrombosis

A

formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what lines the lumen

A

endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are surrounds the basal lamina

A

smooth muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what surrounds the smooth muscle

A

interstitial collagen fibres

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what does lumen contain?

A

red blood cells, white blood cells. platalets, plasma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

are platalets normally exposed to interstitial collagen fibres around the vessel

A

no

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what does plasma consist of

A

water and numerous protiens and other molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what kind of factors does plasma contain?

A

clotting factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is plasma without the clotting factors?

A

serum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

where are clotting factors produced

A

liver, endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what does thrombonin convert …. into ….

A

soluble fibronogen into insoluble fibrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what kind of system is the clotting cascade

A

amplification system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is the initial damage

A

trauma leads to exposed interstitial collagens and exposure of tissue factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what does trauma lead to in vessels

A

defects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what happens when there is a defect in the vessel?

A

blood leaks out and serum comes into contact with the interstitial collagen fibres

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

how are clotting factors activated?

A

when they come in contact with the collagen fibres

17
Q

what is the function of tissue factor when there has been defects in the vessel

A

bind a clotting factor and initiate the clotting cascade

18
Q

why is it important that clotting factors are serine proteases

A

they have a serine amino acid in them and they cleave other clotting factors to form the active molecule

19
Q

what is formed into thrombonin

A

prothrombin

20
Q

what is the endpoint of clotting cascade

A

production of insoluble fibrin strands that form meshwork

21
Q

where are platalets produced?

A

bone marrow

22
Q

what is megakaryocyte

A

large cell with many nuclei

23
Q

can megakaryocytes undergo cell division?

A

no

24
Q

what is platalets role when there is a defect in the vessel

A

platalets try form a bridge to close the gap

25
Q

what is coagulation

A

solidification of blood

26
Q

what are the two types of coagulation

A

thrombosis formation and clot formation

27
Q

what kind of coagulation is formed in flowing blood

A

thrombosis

28
Q

why does thrombosis occur in flowing blood

A

Platelets have molecules on their surfaces which allow adherence to interstitial collagen, even when blood is flowing past them – the clotting cascade deposits Factor VIII which enhances this further

29
Q

how would you describe a blood clot formation

A

blood leaks out off a vessel and becomes stationary

30
Q

what does a clot consist of

A

network of fibrin strands and red blood cells

31
Q

how is haemostasis achieved?

A

vessel vasoconstrics and platalets form bridge

32
Q

what is granulation tissue?

A

new vessels formed around an area of wound

33
Q

what is ischaemia

A

lack of blood flow to tissue

34
Q

how is excess thrombosis or clot removed?

A

In blood there is a fibrinolytic system which removes fibrin and stops thrombi from propagating

35
Q

what does the fibronolytic system depend on?

A

plasma protein called plasminogen being converted to plasmin

36
Q

what does plasmin cut fibrin into?

A

fibrin degradation products

37
Q

what are the three things associated with abnormal thrombosis and clotting

A

Abnormalities of vessel wall
Abnormalities of constituents of the blood
Abnormalities of vessel flow

38
Q

whats haemostasis

A

the stopping of bleeding

39
Q

what is thrombi

A

platalets admixed w fibrin and form in flowing blood

principles of disease (39 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions