hypersensitivity autoimmunity Flashcards
what is the antibody in type 1 hypersensitivity
IgE
what is the action of type 1 hypersensitivity
Immediate hypersensitivity diseases are initiated by the introduction of an allergen, which stimulates TH2 reactions and IgE production. IgE sensitizes mast cells by binding to FcεRI , and subsequent exposure to the allergen activates the mast cells to secrete the mediators that are responsible for the pathologic reactions of immediate hypersensitivity.
type 1 “immediate” recation
mast cell activation
igE mediated effects and vasodialtion
type 1 “late” reaction
Eosinophil, neutrophil and T cell infiltrates
what are the examples of autoimmune disease
systemic and organ specific
systeic autoimmune disease
Autoimmune process is diffuse is spread throughout the body
Affects more than one organ - not necessarily the same ones in different individuals
organ specific autoimmne disease
Autoimmune process directed against one organ
Type 1 Diabetes - pancreas
Autoimmune Thyroiditis
Systemic lupus erythematosus
Relapsing and remitting chronic
systemic disease
Primarily affects women in
20’s - 60’s
define Hypersensitivity responses
damaging responses produced during normal immune responses
describe autoimmune disease
- a failure or breakdown of immune system that maintains tolerance to self tissues
Loss of tolerance is probably due to abnormal selection or lack of control of
self-reactive lymphocytes (B and T-cells)
what is an autoimmune disease
a failure or breakdown of immune system that maintains tolerance to self tissues
what are the 4 catogories of hypersensitivity responses
1, 2, 3 and 4
which hypsensistivity are antibody mediated?
1, 2 and 3
which hypersensitivity is T cell mediated
4
