Therapeutics/toxicology Flashcards by Jessica Radford

Malignant hyperthermia associated with

Anaesthetic agents

How well did you know this?

Not at all

Perfectly

Neuroleptic malignant syndrome associated with which drugs

Antipsychotics
Dopaminergics (Levodopa) if stopped suddenly

How well did you know this?

Not at all

Perfectly

Serotonin syndrome associated with which drugs

SSRIs (includes Tramadol)
MAO inhibitors
Amphetamine/MDMA

How well did you know this?

Not at all

Perfectly

Initial management of theophylline poisoning

Multiple dose activated charcoal

How well did you know this?

Not at all

Perfectly

2nd line management of theophylline poisoning

Haemodialysis/charcoal haemoperfusion

How well did you know this?

Not at all

Perfectly

Features of theophylline poisoning

Hypokalaemia, acidosis
Arrhythmia

How well did you know this?

Not at all

Perfectly

Which medication should be stopped on starting DAPT

Omeprazole - inhibits clopidogrel

How well did you know this?

Not at all

Perfectly

Nitrofurantoin - risks in long-term use

Folate deficiency
Pulmonary fibrosis
SLE-like syndrome

How well did you know this?

Not at all

Perfectly

Uses of doxazosin

Resistant HTN
BPH

How well did you know this?

Not at all

Perfectly

Uses of duloxetine

Depression/anxiety
Neuropathic pain
STRESS incontinence

How well did you know this?

Not at all

Perfectly

1st line management of urge incontinence

Bladder training 6 weeks

How well did you know this?

Not at all

Perfectly

2nd line management of urge incontinence

Anti-muscarinics (oxybutynin > tolteradine)

How well did you know this?

Not at all

Perfectly

2nd line management of urge incontinence if anti-muscarinics not appropriate

Mirabegron (beta-3 agonist)

How well did you know this?

Not at all

Perfectly

1st line management of stress incontinence

Pelvic floor training 3 months

How well did you know this?

Not at all

Perfectly

3rd line management of urge incontinence

Botox

How well did you know this?

Not at all

Perfectly

2nd line management of stress incontinence

Surgery: retropubic mid-urethral tape

2nd line management of stress incontinence - if surgery not appropriate

Duloxetine

Adverse effects of trimethoprim

Myelosuppression
Transient rise in creatinine

Adverse effects of Efavirenz (NNRTI)

Nightmares
Confusion

Adverse effect of Abacavir (NRTI)

Hypersensitivity reaction associated with HLA-B*5701

Side effects of Tenofovir (NRTI)

Renal impairment
GI upset
Osteoporosis

General adverse effects of NRTIs

Peripheral neuropathy
Lactic acidosis

Trastuzumab (anti-HER2/neu) side effects

Cardiotoxicity, especially when anthracyclines (Doxorubicin) have been given

Morbiliform rash + raised eosinophils after starting anti-epileptic/antibiotic/HAART

DRESS (drug reaction with eosinophilia and systemic symptoms)

Management of Amiodarone-induced thyrotoxicosis type 2 (amiodarone-related destructive thyroiditis)

Corticosteroids

Management of Amiodarone-induced thyrotoxicosis type 1 (excess iodine-induced thyroid hormone synthesis)

Carbimazole +/- potassium perchlorate

Aspirin overdose - salicylate serum level requiring haemodialysis

> 700 mg/L

Treatment of methanol poisoning

Fomepizole Folinic acid to prevent opthalmological complications

Features of Cinchonism (quinine toxicity)

Tinnitus Blurred vision Nausea Arrhythma

Poisoning showing high anion gap (>16) and high osmolar gap (10), think..

Ethylene glycol toxicity

Side effects of Pyrazinamide

Arthralgia + myalgia Gout Hepatitis

Indications for desferrioxamine in iron overdose

Serum iron >90 umol/L Serum iron 60-90 and symptomatic, or iron visible on AXR despite irrigation Shock, coma, metabolic acidosis

Acute management of hereditary angioedema

IV C1 esterase inhibitor FFP if not available