Pharmacology Flashcards
Management of opioid-related sickness
Haloperidol, metoclopramide
Medication licensed for motion sickness
Hyoscine hydrobromide
Lesser-sedating antihistamines recommended for motion sickness
Cyclizine
Cinnarizine
Characteristic side effect of Erythromycin
GI upset
QT prolongation
Characteristic side effect of Ciprofloxacin
Lower seizure threshold
Tendonitis
Characteristic side effect of Co-amoxiclav
Cholestasis
Characteristic side effect of Amoxicillin
Rash with EBV
Characteristic side effect of Trimethoprim
Rash, photosensitivity
Pruritis
Haematopoiesis suppression
Characteristic side effect of Doxycycline
Photosensitivity
Drugs which should be prescribed by brand
MR calcium-channel blockers
Antiepileptics
Ciclosporin, tacrolimus
Mesalazine
Lithium
Aminophylline, theophylline
Methylphenidate
CFC-free beclometasone
Dry powder inhalers
P450 Inducers
(reduces effectiveness of COCP)
Phenytoin
Carbamazepine
Barbiturates
Rifampicin
St John’s Wort
Chronic ETOH
Griseofulvin
Smoking
P450 Inhibitors
(increases INR with warfarin use)
Ciprofloxacin
Erythromycin
Isoniazied
Omeprazole
Amiodarone
Allopurinol
Fluconazole
SSRIs
Ritonavir
Sodium valproate
Acute ETOH
Rifampicin side effects
Reduces COCP effectiveness
Hepatitis
Orange bodily fluids
Isoniazid side effects
Enzyme INHIBITor
Peripheral neuropathy
Hepatitis
Agranulocytosis
Psychosis
Pyrazinamide side effects
Gout
Arthralgia, myalgia
Hepatitis
Nausea
Ethambutol side effects
Optic neuritis
Rash
Interact with statins
Macrolides (withhold statin during course)
Which drugs prolong QT
Amiodarone
TCAs
SSRI (esp citalopram)
Chloroquine
Erythromcyin, clarithromycin
Ondansetron
Haloperidol
Methadone
Amiodarone classically increases levels of drugs:
Warfarin
Digoxin
Drugs which may exacerbate HF
Pioglitazone
Verapamil
NSAIDs
Glucocorticoids
Fleicanide
Statin monitoring
LFTs at baseline + 3m + 12m
ACEi monitoring
U&E at baseline + after dose increase + annually
Amiodarone monitoring - baseline
TFT, LFT, U&E, CXR
Amiodarone monitoring - ongoing
TFT + LFT 6-monthly
Methotrexate monitoring - baseline
FBC, LFT, U&E
Methotrexate monitoring - ongoing
FBC, LFT, U&E 1-2wks until stable
Then every 2-3m