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**Bank > Rheum COPY > Flashcards

Rheum COPY Flashcards

1
Q

IgA nephropathy (Berger’s diseae) with systemic vasculitic involvement =

A

IgA vasculitis (Henoch-Schonlein Purpura)

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2
Q

Features of IgA Vasculitis (Henoch-Schonlein Purpura)

A

Purpura on extensors/buttocks

Abdo pain (GI bleeding)

Nephritis

(Polyarthritis)

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3
Q

IgA vasculitis (HSP) usually presents in

A

Children following an infection

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4
Q

anti-scl-70 (anti-topoisomerase) is highly specific for:

A

Diffuse cutaneous systemic sclerosis (+ increased risk pulmonary fibrosis)

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5
Q

anti-centromere is highly specific for:

A

Limited cutaneous systemic sclerosis

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6
Q

anti-dsDNA is highly specific for:

A

SLE

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7
Q

anti-Smith is highly specific for:

A

SLE

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8
Q

anti-Mi-2 is highly specific for:

A

Dermatomyositis
(but only present in 25%)

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9
Q

anti-Jo-1 is seen in

A

Polymyositis (in disease with lung involvement, Raynauds & fever)

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10
Q

Indications for plasma exchange (plasmapharesis)

A

Guillain-Barre

Myasthenia gravis

Goodpastures

ANCA vasculitis with rapidly progressive GN

ANCA vasculitis with pulmonary haemorrhage

TTP/HUS

Cryoglobulinaemia

Hyperviscosity (eg in MM)

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11
Q

Anti-Ro are seen in

A

Sjogrens

Also SLE

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12
Q

SLE and pregnant - Which antibody signifies risk of neonatal heart block

A

Anti-Ro

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13
Q

Initial management of RA

A

DMARD monotherapy (usually methotrexate)

+/- bridging steroids

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14
Q

Other DMARD options in RA

A

Sulfasalazine
Leflunomide
Hydroxychloroquine

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15
Q

Management of RA - inadequate response to DMARDs
(at least 2 DMARDs, including MTX)

A

TNF-inhibitors:
Etanercept
Infliximab
Adalimumab

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16
Q

Before starting TNF-inhibitor

A

Screen for TB, Hep B
(+/-Hep C if risk) due to risk of re-activation

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17
Q

Abatacept (anti-CTLA4) used in

A

RA not controlled with anti-TNF therapy

18
Q

Canakinumab (anti-IL1) used in

A

Gout flares
Resistant Still’s disease

19
Q

Management of RA - next step after TNF inhibition

A

Rituximab (anti-CD20)

20
Q

Tocilizumab (anti-IL6) used in

A

RA not controlled with anti-TNF therapy

21
Q

Management of dermatitis herpetiformis

A

GF diet
Topical dapsone

22
Q

Side effect of dapsone

A

Haemolytic anaemia
Peripheral neuropathy

23
Q

Management of scalp psoriasis

A

Potent topical corticosteroid (Beclomethasone)

24
Q

Features of Adult Onset Still’s Disease

A

Daily fevers
Salmon-pink rash
Oligoarthritis
Serositis

25
Management of Still's disease
NSAIDs -> Steroids -> MTX -> anti-TNF -> anti-IL1 (canakinumab) -> anti-IL6 (Tocilizumab)/anti-CD20 (rituximab)
26
1st line therapy for plaque psoriasis
Topical steroids / Vit D analogues / Dithranol / Coal tar
27
2nd line therapy for plaque psoriasis
UVB light therapy Ciclosporin/MTX
28
3rd line therapy for plaque psoriasis (or with arthritis)
anti-TNF (infliximab)
29
Aspirate findings in pseudogout
Positively birefringent rhomboid crystals
30
Aspirate findings in gout
Negatively birefringent needle-shaped crystals
31
Management of pseudogout
NSAIDs > Steroids > Colchicine
32
Management of gout
NSAIDS/colchicine -> Oral steroids -> IM steroid
33
Alemtuzumab (anti-CD52) is used in
Multiple sclerosis
34
Commonest causes of drug-induced lupus
Hydralazine Procainamide Isoniazid Phenytoin
35
Typical antibodies in drug-induced lupus
anti-dsDNA negative anti-histone positive
36
Features of thromboangiitis obliterans
Young men, smokers Peripheral limb ischaemia Cockscrew vessels Lack of CVD RF Lack of multisystem inflammation
37
Features of antiphospholipid syndrome
VTE Thrombocytopenia Prolonged APTT Livedo reticularis Recurrent fetal loss Pre-eclampsia, pulmonary HTN
38
Management of antiphospholipid syndrome (no previous VTE)
Low-dose aspirin
39
Management of antiphospholipid syndrome (previous VTE)
Lifelong warfarin with INR target 2-3
40
Management of antiphospholipid syndrome (recurrent VTE whilst on warfarin)
Lifelong warfarin INR 3-4 Add aspirin
41
Management of antiphospholipid syndrome (previous arterial thrombosis)
Lifelong warfarin INR 2-3

**Bank (74 decks)

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