Therapeutic Use Of Insulin Flashcards
Differences in synthetic insulin
Injectable
Loss of portal peripheral gradient
Loss C peptide
Cause weight gain
Not controlled endogenously
Narrow therapeutic index
Two types of insulin
Rapid acting
Long acting insulin
Molecular size of insulin correlates with
Absorption from subcutaneous injection sites
Modify insulin toro what?
Make it faster acting or longer lasting
Standard conc of insulin
100 units per ml (called U100)
Basal boils insulin regimen
Basal: long acting insulin twice or once daily
+
Prandial: rapid acting analogues before meals
Measure insulin when
Before meals and before bed
Insulin dose adjustment golden rules
Look for hypos first
Look for a pattern
DAFNE IS
Teach type 1 people about how to manage their insulin
5 day programme
Emphasis on building confidence and appropriate independence
Taught how to adjust insulin to life style
Insulin pump therapy is
Continuous subcutaneous insulin infusion all day
How are type 2 people given insulin?
Basal ( long acting) given pre bed
Measured pre breakfast
If you cahange conc of premixed insulin you must
Also change conc of the other insulin in the premix
Type 1 therapy
Basal boils
Insulin pump
Type 2 therapy
Bedtime insulin
Twice daily mixed
Basal bolus
Side effects of insulin
Hypoglycaemia
Weight gain
Very rarely allergies