Immunology Of Type 1 Diabetes Flashcards
1
Q
Blood glucose measured by?
A
HBA1C
2
Q
Target for diabetic HBA1C
A
6?5-7%
3
Q
Pathology of type 1
A
Pseudoatrophic islets, devoid of beta cells but retaining glucagon and somatostatin
4
Q
Islets of type 1 diabetes
A
Tcells+ B cells+ macrophages
5
Q
How to define an autoimmune condition
A
Evidence of loss of immunological tolerance to self
Passive transfer of disease by immune effectors
(e.g. T cells, antibodies)
Clinical responsiveness to immune suppression, or to
re-establishment of tolerance
6
Q
which studies differentiate between cause and effect?
A
GWAS
7
Q
What kills islets of langerhans
A
Cytotoxic T cells
8
Q
Type1 and type 2 diabetes are
A
Genetically distinct
9
Q
Are antibodies pathogenic
A
No they’re just a sign
10
Q
Giving small bits of allergic stimulation results in?
A
Some T cell formation
