Acute Phase Response Flashcards
Causes of inflammation
Trauma
Burns
Pancreatitis
Chronic inflammation due to autoimmune disorders
Acute phase response to inflammation or infection
- Traumas
- Local response to create pro inflammatory cytokines
- Liver/hepatocytes - modulation of protein synthesis
- Acute phase response
Sepsis is
Serious complication of an infection
TNF a and IL1 does?
Causes fever
Release stress hormones
(norepinephrine, vasopressin, activation of the renin- angiotensin-aldosterone system).
TNF a And IL1
Synthesis of IL 6 IL8 and interferon gamma
Cytokines especially IL6
Stimulate release of acute phase reactants like CRP
APP stands for
Acute phase prot ins
APP used as
Ideal bio markers for inflammation
Role of C reactive protein is
Remove toxic substances from damaged tissue
C reactive protein synthesised where
Liver
C reactive protein useful in
Assessing extent or activity of inflammation
Assessing response to treatment
PCT kinetics provide important info on
Prognosis of sepsis patients