Acute Phase Response Flashcards

1
Q

Causes of inflammation

A

Trauma
Burns
Pancreatitis
Chronic inflammation due to autoimmune disorders

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2
Q

Acute phase response to inflammation or infection

A
  1. Traumas
  2. Local response to create pro inflammatory cytokines
  3. Liver/hepatocytes - modulation of protein synthesis
  4. Acute phase response
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3
Q

Sepsis is

A

Serious complication of an infection

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4
Q

TNF a and IL1 does?

A

Causes fever
Release stress hormones

(norepinephrine, vasopressin, activation of the renin- angiotensin-aldosterone system).

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5
Q

TNF a And IL1

A

Synthesis of IL 6 IL8 and interferon gamma

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6
Q

Cytokines especially IL6

A

Stimulate release of acute phase reactants like CRP

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7
Q

APP stands for

A

Acute phase prot ins

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8
Q

APP used as

A

Ideal bio markers for inflammation

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9
Q

Role of C reactive protein is

A

Remove toxic substances from damaged tissue

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10
Q

C reactive protein synthesised where

A

Liver

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11
Q

C reactive protein useful in

A

Assessing extent or activity of inflammation

Assessing response to treatment

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12
Q

PCT kinetics provide important info on

A

Prognosis of sepsis patients

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