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Inflammation > Coeliac Disease > Flashcards

Coeliac Disease Flashcards

1
Q

CD is

A

Chronic systemic, immune mediated disorder in genetically pre disposed patients

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2
Q

Cd is triggered by

A

Ingesting gluten >- mucosal inflammation, crypt hyperplasia and villous atrophy

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3
Q

How does CD present

A

Non specific GI symptoms, malabsorption/ diarrhoea/ nutritional deficiencies / anaemia/osteoporosis

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4
Q

Untreated CD has

A

Significant morbidity and up to 4 fold increases risk of death

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5
Q

CD can be associated with

A

Other autoimmune conditions

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6
Q

Is CDreversible

A

Potentially reversible villus atrophy in most cases

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7
Q

All patients with CD carry

A

HLA-DQ2 or DQ8

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8
Q

Do HLA genes mean you definitely have CD

A

No 30-50% of population carry these genes but don’t have CD

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9
Q

HLA test is

A

Good negative predictor

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10
Q

Gold standard for CD

A

Duodenal biopsy

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11
Q

Key things to look for in duodenal biopsy

A

Villus atrophy (most important)

Crypt hyperplasia

Intraepithelial lymphocytes

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12
Q

Duodenal histology classification called

A

Marsh

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13
Q

Marsh 1

A

Lymphocytosis increSed

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14
Q

Marsh 2

A

Lymph

Hyperplasia (crypts)

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15
Q

Marsh 3

A

Lymph
Hyperplasia
Villus atrophy

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16
Q

Clinical manifestations of CD

Gastrointestinal

A 
Diarrhoea
Flatulence (farting)
Abdominal cramps
Nutrient deficiency 
Weight loss 
Abnormal liver enzymes
17
Q

Clinical manifestations of CD

Haematological

A

Anaemia
Hyposplenism
Bleeding disorders

18
Q

Cd manifestation NA muscoskeletal

A

Osteopenia+ osteoporosis
Stunted growth in children
Vitamin D deficiency and hyper calcaemia

19
Q

Clinical manifestations CD skin

A

Dermatitis herpetifornis

20
Q

CD neurological manifestations

A

Muscle weakness, paraesthisia , ataxia

Seizures

21
Q

Hormonal CD manifestations

A

Amenorrhoea

Infertility

22
Q

Differential diagnosis for CD

A 
Viral/bacterial enteritis
Chronsdisease 
Small bowel bacteria overgrowth
IBS
microscopic colitis
Protein loosing eneropathy
Malabsorption 
Immunodeficiency

Inflammation (34 decks)

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