SLE

Question 1

Prevalence race

Answer 1

Q/5000 Europeans

1/1000 African

Question 2

Prevalence gender

Answer 2

10:1 female to male

Question 3

Age of onset

Answer 3

30/40s

Question 4

System lupus is.

Answer 4

skin rash caused by complexes of DNA and anti-DNA antibodies becoming localized in the skin to cause inflammation

Question 5

SLE found where

Answer 5

Any organ tissue

Question 6

Common patterns

Answer 6

– Skin (diverse patterns, photosensitivity, alopecia) – Joints (non-erosive arthritis and tendinitis)
– Sicca symptoms (salivary, lacrimal, genital tract)
– Glomerulonephritis (several patterns: mesangial, membranous and peripheral)
– Neurological: CNS, eye, peripheral nervous system

Question 7

Does apoptosis lead to inflammation

Answer 7

No

Question 8

Mechanisms of SLE

Answer 8

Direct cytotoxicity

Immune complex formation and deposition

Trigger pro inflammatory response in cells carrying fc gamma receptors

Promote NK activation

Question 9

Inflammatory arthritis

Answer 9

Rheumatoid

Question 10

How many affected by rheumatoid arthritis

Answer 10

1-2% of population

Question 11

Female to male ratio

Answer 11

3:1

Question 12

Health risk

Answer 12

Crippling disease

Killing disease

Question 13

Rheumatoid arthritis is?

Answer 13

Systemic autoimmune disease of unknown aetiology

Mainly in joints

Extraarticular involvement

Chronic inflammatory disease