Inflammatory/ Autoimmune Skin Disease

Question 1

What suggested disease is chronic

Answer 1

Scales

Question 2

Plaque is

Answer 2

Raised more than 1 cm

Question 3

Nail changes in psoriasis

Answer 3

Oil drop

Pitting

Question 4

Psoriasis is not always scaly sometimes

Answer 4

Inverse psoriasis can be fissured

Question 5

Genital psoriasis often

Answer 5

Often missed or misdiagnosed as Candida /fungal

Question 6

How prominent is psoriasis

Answer 6

Occurs 1-2% of population

Question 7

Family history of psoriasis

Answer 7

1/3 of people

Question 8

Psoriasis symptoms

Answer 8

Increased cell turnover, vasodilation

Question 9

Precipitating factors of psoriasis

Answer 9

Streptococcal pharyngitis or other infections

Emotional stress

Physical trauma

Drugs: lithium, b blockers, NSAIDs and anti malaria as

HIV infection

Question 10

Psoriasis often comes with

Answer 10

Comorbidity (drinking and smoking)

Question 11

Psoriatic arthritis

Answer 11

Asymmetric (one joint): small joint involvement

Symmetric :rheumatoid arthritis- like, Rf negative

Distal interphalangeal joint disease : sausage digits

Ankylosing spondylitis (back)

Arthritis mutilans: osteolysis of small bones hands and feet (extension of bones)

Question 12

Treatment options

Answer 12

Topicals

Phototherapy

Methotrexate

Biologics

Question 13

Anti TNF

Answer 13

Chimeric I flick an
Human adalimumab

Fusion protein etanercept

Question 14

Anti IL 12/23 drugs

Answer 14

Human ustekinumab

Question 15

Anti IL -17

Answer 15

Human secukinumab

Question 16

Erythroderma Means

Answer 16

90% of body surface area involvement

Question 17

Erythroderma symptoms

Answer 17

Temp regulation
Fluid balance
Hypovolaemia
Hypoalbuminemia

Question 18

Erythroderma causes

Answer 18

Drug eruption
Dermatitis 
Psoriasis
Pityriasis rubra piliris
Infection 
Blistering 
Sezay syndrome

Question 19

Atopic dermatitis

Answer 19

Chronic, relapsing, skin disorder associated with a personal or fam history

Atopic March

Intense pruritis

Question 20

Atopic dermatitis prevalent in

Answer 20

60% develop in first year of life

Rarely occurs for first time in adulthood

50% of patients with atopic dermatitis eventually develop allergic rhinitis or athsama

Question 21

Filaggrin gene mutation causes what

Answer 21

Horny layer to be broken 
Granular layer (keratohyaline granuels) missing

Question 22

How to manage filaggrin gene mutation

Answer 22

Put topical steroid on

Moisturise skin to preserve barrier

Question 23

Atopic dermatitis course and complications

Answer 23

Chronic disease with reccurrent flares

Most children outgrow disease
Some adults still have localised dermatitis.

Frequent infection on skin- higher rate of colonisation with s.aureus

Herpes simplex infection may result in eczema

Question 24

Atopic dermatitis treatment

Answer 24

Skin care emollients, baths

Topical steroid

Wet dressing

Avoid environmental factors

Severe cases PUVA UVB MTX azathioprine

Biologics