Tetracyclines Flashcards
Rickettsia (Rocky mountain spotted fever)
Doxycycline
Borrelia Bergdorferi (tick born lyme disease)
Doxycycline
Chlamydia trachomatis
Doxycycline
cidal or static
static
mechanism of resistance
- tetracycline efflux pump
- methylation of ribosome
What is the name of the efflux pump that conveys resistance
Tet A
What is the only tetracycline that is safe to use in renal impairment
Doxycycline
Adverse effects of tetracyclines
- GI superinfection
- Accumulation in teeth and bone
- Fatal hepatotoxicity (fatty liver during pregnancy)
- Phototoxicity
- Vestibular probems
- Diabetes insipidus
What should you not take with tetracyclines because it disrupts absorption
- antacids
- dairy food
What age are tetracyclines contraindicated for?
under 8 due to accumulation in teeth and bones
3 people that tetracyclines are contraindicated for?
- pregnant
- breast feeding
- children under 8
What is the super infection that can develop in the GI tract when taking tetracyclines
-C. diff causing a potentially life threatening pseudomembranous colitis
What is the improved relative of tetracyclines that is save for patients with renal impairment, has decreased susceptibility by Tat A efflux pumps, and has a greater spectrum of activity
Tigecycline
MOA for tetracyclines
Block binding of aminoacyl-tRNA
metabolism
enterohepatic recirculation
