Hersh Tb lecture

Question 1

Weakly G+ rod, branching filaments, aerobic

Answer 1

Nocardia

Question 2

G+ rod, spore forming, aerobic

Answer 2

Bacillus anthracis

Question 3

Weakly G+ rod, non-motile, aerobic

Answer 3

mycobacterium tuberculosis

Question 4

G+ rod, spore forming, anaerobic

Answer 4

Clostridium sp

Question 5

G+ rod, motile, anaerobic

Answer 5

Listeria monocytogenes

Question 6

Initial stain to SCREEN for Tb

Answer 6

Auramine-rhodamine stain

Question 7

Stains to CONFIRM Tb

Answer 7

• Ziehl-Neelsen

- Kinyon

Question 8

NAAT tests for resistance to what?

Answer 8

Rifampin and INH

Question 9

add this to 4 drug Tb treatment because of vitamin deficiency

Answer 9

Pyridoxine (B6)

Question 10

Tb drug that causes eye issues

Answer 10

Ethambutol

Question 11

Thoracentesis of patient with suspected Tb will contain what

Answer 11

Positive adenosine deaminase

Question 12

What do you typically see with primary progressive Tb

Answer 12

pleural effusion

Question 13

Tb virulence factors

Answer 13

• cord factor (release cachectin - wt loss, inhibit phagosome)
• Sulfatides (inhibit phagasome-lysosome fusion)
• Siderophore (Fe2 acquisition)

Question 14

What does Primary progressive Tb look like

Answer 14

it can lead to miliary Tb and looks like pneumonia

Question 15

Most common extrapulmonary manifestation of Tb

Answer 15

lymphadenitis . . . SCROFULA

Question 16

Mycobacerium Kansaii is seen in what kind of patients

Answer 16

-older patients with underlying lung disease or long time smokers in midwest and south west US

Question 17

Treatment for Mycobacterium Kansaii

Answer 17

Rifampin, Isoniazid, and ethambutol for 18 MONTHS

Question 18

Lepromin test in tuberculoid leprosy

Answer 18

positive

Question 19

lepromin test in lepromatous leprosy

Answer 19

negative

Question 20

Granulomatous lesion of the skin and tendon sheaths after exposure to fish tank or aquarium water

Answer 20

M. marinum