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Respiratory Medicine > Sulfa drugs > Flashcards

Sulfa drugs Flashcards

1
Q

What enzyme do sulfonamides inhibit?

A

dihydropteroate synthase

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2
Q

What combo leads to synergistic antibiotic coverage

A

sulfamethoxazole/Trimethoprim (TMP-SMX)

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3
Q

What enzyme does Trimethoprim (TMP) inhibit?

A

dihydrofolate reductase

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4
Q

Main condition that sulfonamide and trimethoprim treat?

A

UTIs; prostatitis and cystitis

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5
Q

used in treatment of pneumocystis jiroveci pneumonia (PJP) and also prophylaxis in HIV patients?

A

TMP-SMX

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6
Q

Used in treatment of Toxoplasmosis encephalitis and prophylaxis for HIV patients?

A

TMP-SMX

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7
Q

do sulfanomides treat MRSA?

A

yes

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8
Q

Adverse effects of sulfonamides?

A
  • LIFE THREATENING Hypersensitivity (Stevens-Johnson)
  • Kernicterus
  • Hemolytic anemia (X-linked G6PD deficiency)
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9
Q

sulfonamides and pregnancy and neonatal period (breast feeding)

A

NOOO. kernicterus

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10
Q

What birth defects can Trimethoprim cause?

How would you prevent this?

A

Cardiovascular defects and oral clefts

Supplement with folate

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Respiratory Medicine (37 decks)

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