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Respiratory Medicine > Asthma and COPD drugs > Flashcards

Asthma and COPD drugs Flashcards

1
Q

what are the 2 high potency inhaled corticosteroids?

A
  • Budesonide

- Fluticasone

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2
Q

Why is systemic exposure to ICS limited?

A

has extensive 1st pass metabolism (good thing in this case)

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3
Q

When taking an ICS what is the concern for children?

Adults?

Post menopausal women?

A
  • impairment of growth
  • oral candidiasis (thrush) or opportunistic yeast infection
  • Osteoporosis
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4
Q

What are the two combos of ICS and LABA used for moderate persistent asthma

A
  • budesonide/formoterol

- Fluticasone/salmeterol

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5
Q

Why are LABAs not used alone?

A

increased risk of death

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6
Q

Black Box Warning for Salmeterol

A

-may increase risk of asthma related death

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7
Q

Side effects of SABAs and LABAs

A
  • hypokalemia

- Hyperglycemia

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8
Q

What leukotriene modifier do you use for children >12

A

Zileuton

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9
Q

What leukotriene modifier for children >5

A

Zafirlukast

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10
Q

What leukotriene modifier for children >1

A

Montelukast

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11
Q

Adverse effects of leukotriene modifiers

A

liver toxicity

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12
Q

What is used to blunt allergic reaction ONLY when environmental or occupational allergens provoke asthma

A

omalizumab

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13
Q

Boxed warning for Omalizumab

A

Anaphylaxis

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14
Q

What is the short acting anti-muscarinic used for COPD?

dosing?

A

Ipratropium

3-4 x a day

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15
Q

What is the long acting anti muscarinic for COPD?

Dosing?

A

Tiotropium

once a day

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16
Q

What is the role of leukotriene modifiers in management of COPD?

A

NO ROLE

17
Q

Should you use systemic glucocorticosteroids in COPD?

A

NO .. risk of infection

18
Q

What are the 2 SABAs that are only oral

A
  • Metaproterenol

- Terbutaline

19
Q

Systemic used of glucocorticoids is associated with what major adverse effects?

A
  • Impaired wound healing
  • Psychosis
  • Osteroporosis
  • HTN
  • Glaucoma
20
Q

Exercise induced asthma?

A

Leukotriene modifiers

21
Q

Oral PDE-4 inhibitor that reduces risk of COPD exacerbations

A

Roflumilast

Respiratory Medicine (37 decks)

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