Fluoroquinolones Flashcards
1
Q
MOA of fluoroquinolones
A
-inhibit DNA gyrase (topoisomerae II) and topoisomerase IV
2
Q
Enzyme targeted in Gram negatives with Fluoroquinolones?
Gram positives?
A
DNA gyrase (topoisomerase II)
Topoisomerase IV
3
Q
mechanisms of resistance to fluoroquinolones?
A
- mutation of DNA gyrase/topoisomerase
- Decreased number of porins
4
Q
What products should not be taken orally with fluoroquinolones because they lower the bioavailability
A
- antacids
- milk/yogurt
- vitamins with iron or zinc
5
Q
Adverse effects of fluoroquinoliones
A
- carilage erosion in pediatrics
- tendon rupture in geriatrics and adults
- phototoxicity
- PROLONGED QT
6
Q
Big red box special alert for fluoroquinolones?
A
-peripheral neuropathy except with topical forms
