Antiviral drugs Flashcards
ultimately the nucleotide triphosphates inhibit what?
Viral DNA polymerase
Preference for Acyclovir
HSV-1 > HSV-2»_space; VSV=EBV (NOT CMV)
TREAMENT and PREVENTION for 1 year and older
Oseltamivir
Which antiviral drugs only blocks influenza A
Amantadine
Ideal time to administer flu antivirals
, 48 hours of symptoms appearing
Which antiviral drugs block both influenza A and B
Oseltamivir and Zanamavir
Clinical indications for Ganciclovir
Treatment and suppression of CMV retinitis in immunocompromised patients
and
Prevention of CMV disease in transplant patients
What causes the mono phosphorylation of drugs in CMV?
UL97 kinase
Blocks viral M2 ion H+ channels and prevents uncoating
amantadine
Acyclovir complications
- acute renal failure
- neurologic toxicity
what converts the nucleotide monophosphates into di,tri phasphates . . .
HOST cell kinases
Ganciclovir complications
- bone marrow suppression
- hematologic and renal toxicity
Which neuraminidase inhibitor is oral?
inhaled?
Oseltamivir
Zanamivir
Which neuraminidase inhibitor can cause nausea?
bronchospasm in asthmatics?
Oseltamivir
Zanamivir
flu Antivirals reduce what things?
- duration of symptoms by 1-2 days
- anti-pyretic
- viral shedding
- complications
What drugs treat CMV?
- Ganciclovir
- Valganciclovir (these first two are nucleoSides)
- foscarnet
What drugs treat Herpes and Zoster?
Acyclovir and valacyclovir
Zanamivir is indicated for TREATMENT of what age
7 and older
Preference for Valacyclovir
similar to acyclovir but NOT EBV and yes to CMV
Zanamivir is NOT RECOMMENDED for who?
- asthma
- COPD
- respiratory disease
Neuraminidase inhibitors
Oseltamivir and Zanamavir
What drug treats acyclovir resistant herpes and zoster
Foscarnet
What causes the mono-phosphorylation of drugs in HSV and VZV?
thymidine kinase
Zanamivir is indicated for PREVENTION of what age
5 and older
