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Respiratory Medicine > Antiviral drugs > Flashcards

Antiviral drugs Flashcards

1
Q

ultimately the nucleotide triphosphates inhibit what?

A

Viral DNA polymerase

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2
Q

Preference for Acyclovir

A

HSV-1 > HSV-2&raquo_space; VSV=EBV (NOT CMV)

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3
Q

TREAMENT and PREVENTION for 1 year and older

A

Oseltamivir

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4
Q

Which antiviral drugs only blocks influenza A

A

Amantadine

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5
Q

Ideal time to administer flu antivirals

A

, 48 hours of symptoms appearing

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6
Q

Which antiviral drugs block both influenza A and B

A

Oseltamivir and Zanamavir

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7
Q

Clinical indications for Ganciclovir

A

Treatment and suppression of CMV retinitis in immunocompromised patients

and

Prevention of CMV disease in transplant patients

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8
Q

What causes the mono phosphorylation of drugs in CMV?

A

UL97 kinase

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9
Q

Blocks viral M2 ion H+ channels and prevents uncoating

A

amantadine

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10
Q

Acyclovir complications

A
  • acute renal failure

- neurologic toxicity

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11
Q

what converts the nucleotide monophosphates into di,tri phasphates . . .

A

HOST cell kinases

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12
Q

Ganciclovir complications

A
  • bone marrow suppression

- hematologic and renal toxicity

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13
Q

Which neuraminidase inhibitor is oral?

inhaled?

A

Oseltamivir

Zanamivir

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14
Q

Which neuraminidase inhibitor can cause nausea?

bronchospasm in asthmatics?

A

Oseltamivir

Zanamivir

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15
Q

flu Antivirals reduce what things?

A
  • duration of symptoms by 1-2 days
  • anti-pyretic
  • viral shedding
  • complications
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16
Q

What drugs treat CMV?

A
  • Ganciclovir
  • Valganciclovir (these first two are nucleoSides)
  • foscarnet
17
Q

What drugs treat Herpes and Zoster?

A

Acyclovir and valacyclovir

18
Q

Zanamivir is indicated for TREATMENT of what age

A

7 and older

19
Q

Preference for Valacyclovir

A

similar to acyclovir but NOT EBV and yes to CMV

20
Q

Zanamivir is NOT RECOMMENDED for who?

A
  • asthma
  • COPD
  • respiratory disease
21
Q

Neuraminidase inhibitors

A

Oseltamivir and Zanamavir

22
Q

What drug treats acyclovir resistant herpes and zoster

A

Foscarnet

23
Q

What causes the mono-phosphorylation of drugs in HSV and VZV?

A

thymidine kinase

24
Q

Zanamivir is indicated for PREVENTION of what age

A

5 and older

Respiratory Medicine (37 decks)

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