Macrolides and Ketolides Flashcards
1
Q
Drug of choice for Legionnaires disease
A
Azithromycin
2
Q
Treponema pallidum (syphilis)
A
Erythromycin
3
Q
What is a major indication for Macrolide/Ketolide
A
URI or CAP (aypticals also)
4
Q
Dose for Azithromycin
A
once daily for FIVE days
5
Q
mechanism of action
A
50s ribosome
6
Q
What step of DNA sysnthesis do macrolides inhibit
A
translocation
7
Q
mechanism of resistance
A
- efflux pumps (MEF E)
- Methylases encode erm (erythromycin ribosome methylase) which alters macrolide binding
8
Q
Adverse effects
A
- GI
- Hepatotoxicity
- QT intervall prolongation
- CYP3A interaction
- Reversible hearing loss
9
Q
What macrolides are safest in pregnancy
A
- erythromycin
- Azithromycin
10
Q
Cover multi drug resistant S. PNEUMONIA
A
Telithromycin (ketolide)
11
Q
act on MRSA?
A
NO
12
Q
What organisms are intrinsically resistant to macrolide/ketolides?
A
- Enterobacteriaceae
- Acinetobacter
- pseudomonas
13
Q
Erythromycin increases risk of what adverse effect?
A
sudden cardiac death
