Test2: Wk8: 3 Inhibitors of the RAAS - Salisbury

Question 1

Function of RAAS

Answer 1

adaptive pathway that mediates Na and Water retention to restore BP during periods of decreased BP

Question 2

ACEIs Mechanism

Answer 2

Prevent ATII formation 
⬇ aldosterone
⬇ ATII vasoconstriction
⬇ neuronal release of NE 
⬇ cardiac, vascular, glomerular remodeling
⬆ BK/PG
⬇ VC EA

Question 3

ACEI effects

Answer 3

⬇ TPR
⬇ Na and H2O retention
⬆ K retention
⬇ BP
⬇ GFR

Question 4

— have renoprotective effects

Answer 4

ACEIs

Question 5

ANGII effects —, —, and, —

Answer 5

EA, Mesangial Cells, Mesangial Matrix

Question 6

ACEI suffiix

Answer 6

pril

Question 7

ACEIs are prodrugs except

Answer 7

captopril and lisinopril

Question 8

Most ACEI are — eliminated

Answer 8

renal

Question 9

ACEIs with hepatic and renal metabolism

Answer 9

Fosinopril

Question 10

ACEIs uses

Answer 10

Hypertension

CHF

Post Mi

Question 11

ACEIs renal protective effects

Answer 11

decrease intraglomerular pressure and prevent further damage

decrease mesangial proliferation, matric expansion and thickening of glomerular basement membrane

Question 12

ACEIs adverse effects

Answer 12

Hypotension. Teratogen, Cough, Angioedema, Hyperkalemia, increase serum Creatine

Question 13

ACEIs contraindications/ precautions

Answer 13

Pregnancy

Low renal Blood Flow

Question 14

ACEIs compromise — contriction

Answer 14

EA

Question 15

ACE inhibitors Contraindications/precautions

Answer 15

Hyperkalemia
•
K sparing diuretics
•
Non selective ꞵblockers
•
K supplements

Question 16

Drug interactions with ACEIs

Answer 16

K sparing diuretics, K
supplements, non selective Beta blockers
(antagonism of ꞵ2 will ↓ K + uptake by skeletal

Question 17

— may worsen ACEIs cough

Answer 17

Capsaicin

Question 18

AT 1 Receptor antagonists suffix

Answer 18

-tan

Question 19

ARBs inhibit

Answer 19

AT1 R

Question 20

ACEIs are more likely to promote venodilation (preload) than ARBs because ACEIs increase
—.

Answer 20

bradykinin

Question 20

ACEIs are more likely to promote venodilation (preload) than ARBs because ACEIs increase
—.

Answer 20

bradykinin

Question 21

ACEIs are more likely to promote venodilation (preload) than ARBs because ACEIs increase
—.

Answer 21

bradykinin

Question 22

— only approved direct renin inhibitor

Answer 22

Aliskiren

Question 23

Aliskiren inhibits

Answer 23

Angiotensinogen conversion to Angiotensin I by Renin

Question 24

Aliskiren Therapeutic Uses

Answer 24

Hypertension