Test 3: Wk11: 7.1 Gas Transport and Diffusion - Dasgupta Flashcards

1
Q

there is a direct correlation between the partial pressure of gasses and

A

the concentration of gasses

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2
Q

0.3 % Vol O2 in plasma = PaO2 100 mmHg

then 0.6% Vol O2 in plasma =

A

200 mmHg

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3
Q

O2 is carried in what two forms in the blood

A

dissolved in plasma and bound to hemoglobin

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4
Q

O2 solubility

A

very insoluble

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5
Q

amount of O2 dissolved in arterial blood in lungs

A

0.3 ml O2 /100ml

3 ml O2 / L

0.3 vol %

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6
Q

partial pressure of oxygen is due to dissolved oxygen in plasma not

A

oxygen bound to hemoglobin

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7
Q

each molecule of Hb binds to — molecules of O2

A

4

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8
Q

majority of O2 in blood is bound to

A

Hb

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9
Q

O2 available to tissues is through

A

dissolved O2

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10
Q

Hb is a — for oxygen

A

buffer/ reservoir

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11
Q

Capillary PO2 deoxygenated

A

40 mmHg

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12
Q

gasses move

A

down partial pressure gradients

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13
Q

O2 dissociates from – and goes into solution in plasma

A

Hb

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14
Q

Dissolved gas diffuses — into interstitial space

A

down partial pressure gradient

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15
Q

PO2 in arterial blood

A

100 mmHg

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16
Q

Hb saturation arterial blood

A

97.4 %

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17
Q

PO2 in venous blood

A

40 mmHg

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18
Q

Hb saturation venous blood

A

75%

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19
Q

Amount of oxygen bound to Hb=

A

1.34 X amount of hemoglobin X % of Hb saturated with oxygen.

20
Q

Arterial oxygen content %

A

19.8 volume %

21
Q

Venous oxygen content %

A

14.8 volume %

22
Q

volume % of O2 unloaded to tissue

A

5%

23
Q

Hb protects tissue from

A

large fluctuations in O2 partial pressure

24
Q

In anemia PVO2 is

A

decreased

25
Q

Hb affinitiy for Co is —

A

200x more than O2

26
Q

O2 Capacity

A

maximal amount of oxygen Hb is capable of carrying. Does not include dissolved oxygen

27
Q

O2 Capacity in polycythemia (high Hb)

A

increased

28
Q

O2 capacity in Anemia (Low Hb)

A

decreased

29
Q

O2 capacity in CO poisoning

A

decreased

30
Q

O2 capacity =

A

O2 content - O2 dissolved

31
Q

Hb saturation =

A

Hb saturation = O2 bound to Hb / O2 capacity x 100

32
Q

Pulse Oximeter measures

A

saturation of Hb by using wavelengths

33
Q

Normal Arterial pH

A

7.36-7.45

34
Q

Normal Arterial PO2

A

80-100mmHg

35
Q

Normal Arterial PCO2

A

35-45

36
Q

Normal Arterial HCO3

A

23-28 meg/ml

37
Q

Normal Arterial O2 saturation

A

95-100%

38
Q

P50

A

partial pressure of O2 when Hb is 50% saturated

approx 26mmHg

39
Q

Hb curve shift right

A

lower affinity for O2

40
Q

Hb curve shift left

A

higher affinity for O2

41
Q

What happens to Hb and P50 during exercise

A

Hb unloads more O2

P50 increases

42
Q

CO2 transported 3 ways

A

dissolved in plasma
as HCO3
bound to Hb

43
Q

CO2 can diffuse times as rapidly as O2

A

20

44
Q

Hambruger/ Chloride Shift

A

Cl goes into RBC as HCO3 leaves to maintain electroneutrality

reverse in lung

45
Q

CO2 reacts with deoxygenated Hb to form

A

carbamino compounds

46
Q

% CO2 transported as carbamino compounds

A

5%

Hb has loww affinity for CO2