Test 3 Cardio drug interactions

Question 1

Beta-blocker with calcium channel blocker

Answer 1

– Additive hypotension and bradycardia
– Negative inotropic effects
– Slowed AV conduction

Question 2

Beta-blocker with calcium channel blocker decreasing intensity

Answer 2

– Verapamil most significant
– Diltiazem next
– Amlodipine last

Question 3

What are the monitoring parameters for cardiovascular drug interactions?

Answer 3

• pulse rate
• blood pressure
• dizziness
• dyspnea
• lethargy / fatigue

Question 4

ACE Inhibitor and potassium-sparing diuretic / calcium channel blockers

Answer 4

– Dyazide or spironolactone combined with enalapril, lisinopril or ramipril
– potential for hyperkalemia
– decrease in circulating aldosterone + potassium sparing diuretic

Question 5

risk factors

Answer 5

• high dosage
• elderly
• CHF
• comorbid
• diabetes
• reduced renal flow / CKD

Question 6

management of ACE Inhibitor and potassium-sparing diuretic / calcium channel blockers

Answer 6

• change to diuretic that we don’t have to worry about this problem in m
• monitor potassium levels within a week of starting these meds together

Question 7

ARB and Potassium-sparing diuretic

Answer 7

– Dyazide combined with valsartan
– potential for hyperkalemia
– blockade of angiotensin II receptor (decreased aldosterone release) + potassium-sparing diuretic

Question 8

management of ARB and Potassium-sparing diuretic

Answer 8

• change to diuretic that we don’t have to worry about this problem in m
• monitor potassium levels within a week of starting these meds together