Test 1 Neurotransmitter reuptake inhibitors

Question 1

drugs

Answer 1

• Elavil
• Pamelor
• Tofranil
• Nardil

Question 2

Elavil

Answer 2

• amitriptyline
• tricyclic antidepressant
• potentiates activity of NE and 5HT by blocking their reuptake
• anticholinergic effect -> cause drowsiness, dry mouth, urinary difficulty
• off label use: sleep, neuropathic pain
• 40 - 150 mg in divided doses or qhs

Question 3

Pamelor

Answer 3

• nortriptyline
• tricyclic antidepressant
• 75 - 150 mg daily

Question 4

Tofranil

Answer 4

• imipramine
• tricyclic antidepressant
• used for depression, prevent bed wetting in children
• determine pediatric weight: max of 2.5mg/kg/day; anything over will cause cardiotoxicity
• 50 - 75 mg qhs
• PM capsules: 50 - 150 mg daily

Question 5

Nardil

Answer 5

• phenelzine
• nonselective monoamine oxidase inhibitor
• used for depression
• food restriction: tyramine
• several drug interactions