Test 3 Antiemetic

Question 1

Zofran®

Answer 1

• ondansetron
• Selective 5-HT3 receptor antagonist
• Chemotherapy induced N & V
• post-operative induced N/V

Question 2

Phenergan®

Answer 2

• promethazine
• also antihistamine
• can cause drowsiness
• can cause risk of fatal resp. depression for children under 2 years of age

Question 3

Compazine®

Answer 3

• prochlorperazine
• also antipsychotic
• should only be used short term
• not used as much but can be used if other drugs are not working
• can cause drowsiness
• adverse effect: abnormal muscle tone with excessive doses or prolonged use

Question 4

Reglan®

Answer 4

• metoclopramide
• inhibition of dopamine activity
• pro-motility agent; take 30 min before eating
• used for: diabetic gastroparesis, symptomatic GERD
• can cause drowsiness
• adverse effect: abnormal muscle tone with prolonged use

Question 5

Antivert®

Answer 5

• meclizine
• anti-vertigo agent
• antihistamine and anticholinergic
• for motion sickness
• can cause drowsiness and dry mouth
• available OTC as Bonine

Question 6

Lomotil®

Answer 6

• diphenoxylate / atropine
• CV
• Antidiarrheal agent
• atropine is to make sure that ppl do not abuse as iv drug
• adjunct in management of diarrhea
• can cause drowsiness and dry mouth
• counseling: discontinue using if it does not work within 48 hours

Question 7

Imodium AD®

Answer 7

• loperamide
• Antidiarrheal agent
• Used for management of diarrhea
• start with two tablets at first stool; take one tablet for every loose stool thereafter
• max of 4 tab per day
• max of 2 days