Test 2 - lymph, immunity, respiration Flashcards
Lymphatic system does what
returns fluids that have leaked from the vascular system back to the blood.
3 parts of the lymphatic system
lymph vessels, lymph (fluid) and lymph nodes
Lymphoid organs and tissues
lymph nodes, spleen, tonsils, and mucosal-associated lymphoid tissues (MALT)
organs included in the lymphoid organs and tissues
spleen, thymus, tonsils and the other lymphatic tissues scattered throughout the body and lymph nodes.
Lymph
clear water. The interstitial fluid that enters the lymphatic vessels is called lymph.
diffuse lymphatic tissue
A loose arrangement of lymphoid cells and some reticular fibers. is found in virtually every body organ. not concrete or specific boundaries. Usually found under the skin or mucous membranes.
Lymph nodes
Filter lymph and house lymphocytes. They have a connective tissue capsule around the outside, highly vascularized they have Afferent vessels that bring the lymph in. leaves through the Efferent vessels, hillus is where the vessels enter and exit
Spleen
has two parts, white pulp and red pulp. It removes the bloodborne pathogens and aged red blood cells
red pulp of spleen
is more vascularized. is where worn-out red blood cells and bloodborne pathogens are destroyed.
white pulp of spleen is
less vascularized. Where immune function takes place
What matures in the thymus gland
is where the t cells go to mature.
What happens to the thymus gland as people age
it shrinks and becomes harder to see or find.
Thymus also secretes
hormones that help with immunity
tonsils are lymph
nodules not as complicated in structure
different types of tonsils
palatine, lingual, pharyngeal
peyer’s patches
aggregated lymphoid nodules - large clusters of lymphoid follicles. located in teh walls of the distal portion of the small intestine.
lymphoid tissue
is an important component of the immune system because it houses and provides proliferation sites for lymphocytes, furnishes an ideal surveillance vantage point for lymphocytes and macrophages,
lymphoid tissue is largely composed of
loose connective tissue called reticular connective tissue which dominates all the lymphoid organs except the thymus.
lymphoid follicles (lymphoid nodules)
solid, spherical bodies consisting of tightly packed lymphoid cells and reticualr fibers.
lymphoid organs are grouped into two functional categories, what are they?
The primary lymphoid organs and the secondary lymphoid organs
primary lymphoid organs
where B and T cells mature. The red bone marros and the thymus.
Secondary lymphoid organs
are where mature lymphocytes first encounter their antigens and are activated.
lymph node has two histologically distinct regions
The cortex and the medulla
cortex of the lymph node has what kind of cells
B cells
medulla of the lymph node has what kind of cells
T cells
path of lymph through the lymph node
lymph enters the convex side of the lymph node through a number of AFFERENT lymphatic vessels, then to the SUBCAPSULAR SINUS, MEDULLARY SINUSES AND EXITS THE HILUM, exits through EFFERENT lymphatic vessels
MALT
mucosa-associated lymphoid tissues. a set of distributed lymphoid tissues strategically located in mucous membranes throughout the body. they guard the bodies entryways against pathogens.
organs in the MALT
tonsils, peyer’s patch, appendix
T lymphocytes mature in the
Thymus
Which of the following is/are the most specific internal defense against disease?
T Cells
T cells are a part of ___(whaty type of defensives?_____
the adaptive (specific) defenses against disease. They are involved in cell-mediated immunity as they defend the body against specific pathogens.
Which of the following provides a first line of defense against pathogens?
skin and mucous.
The first line of defense against disease is
intact skin and mucous membranes. If an antigen (pathogen) cannot enter the body, a secondary defense is unnecessary.
Antigen-presenting cells (APCs) include
macrophages, dendritic cells, and B lymphocytes (B cells).
Which of the following is not an antigen-presenting cells (APC)?
dendritic cell
B cell
macrophage
T cell
t-cell
Vaccines provide what type of immunity?
artificially acquired active
When your B cells encounter antigens and produce antibodies against them, you are exhibiting
active humoral immunity.
T lymphocytes mature in the
Thymus
Which of the following is NOT a chemical barrier that helps prevent infections?
PH of the Blood
Although the blood is usually sterile, the slightly alkaline pH does
not prohibit pathogen growth.
Which of the following would be a component of the body's first line of defense? phagocytes inflammation mucous membranes natural killer cells
mucous membranes
Four (or five) cardinal signs indicate inflammation. What specific sign of inflammation is the result of exudate in the tissue spaces? impaired function pain edema (swelling) heat
edema (swelling)
Edema is caused when
release of fluids from blood vessels exceeds their uptake.
Not only is blood flow increased to inflamed areas, but capillaries are made more permeable to fluid, resulting in
loss of fluid from the blood and tissue swelling.
Which of the following inflammatory chemicals is/are released by mast cells?
Histamine
What cells are similar to mast cells but live in the blood and release histamine?
basophils
Which of the following is NOT one of the effects produced by the release of inflammatory chemicals?
redness
vasoconstriction
increased access of clotting chemicals
attraction of neutrophils
vasoconstriction
Inflammatory chemicals dilate, rather than constrict, local arterioles and make local capillaries more
permeable.
When do neutrophils enter the blood from the red bone marrow in response to leukocytosis-inducing factors?
Leukocytosis
Interferon is
a small protein that can stimulate nearby healthy cells to defend themselves against viral infection.
What protein can be released by infected cells to help protect cells that have not yet been infected? opsonins complement interferon pyrogens
interferon
How do interferons protect against viral infection in healthy cells?
Interferons encourage the production of antiviral proteins.
Which antimicrobial protein triggers inflammation?
complement
pyrogen
interferon
complement
Discharge is one of the cardinal signs of inflammation.
Discharge is one of the cardinal signs of inflammation.
True
False
false
Which of the following is an effect of complement activation?
Which of the following is an effect of complement activation?
fever
T cell activation
opsonization
tissue repair
opsonization
Complement proteins stimulate inflammation, serve as
opsonins to aid in the phagocytosis of targeted antigens, and facilitate cytolysis.
Which cells secrete histamines that trigger inflammatory pathways?
Which cells secrete histamines that trigger inflammatory pathways?
neutrophils
mast cells
macrophages
NK cells
mast cells
Mast cells have granules that contain
histamines.
Phagocytes are unable to adhere to bacteria that have external capsules concealing their membrane carbohydrates. Our immune system gets around this problem by coating such pathogens with __________.
phagosomes
opsonins
mucin
toll-like receptors
opsonins
Opsonins are
complement proteins or antibodies; both provide “handles” to which phagocyte receptors can bind. Any pathogen can be coated with opsonins, a process called opsonization (“to make tasty”), which greatly accelerates phagocytosis of that pathogen.
Provide Feedback
During inflammation, fluids will passively diffuse out of blood vessels into the nearby infected tissues. This implies all of the following EXCEPT ________.
B-lymphocytes will differentiate to become plasma cells
The redness and heat of an inflamed area are due to a local hyperemia caused by ________.
vasodilation
opsonization
is the process of making pathogens more susceptible to phagocytosis by decorating their surface with molecules that phagocytes can bind. Antibodies and complement proteins are examples of molecules that act as opsonins.
Which of the following is NOT a role of activated complement?
insertion of MAC and cell lysis
opsonization
enhancement of inflammation
prevention of immediate hypersensitivity reactions
prevention of immediate hypersensitivity reactions
Interferons_______
- are virus-specific, so that an interferon produced against one virus could not protect cells against another virus
- act by increasing the rate of cell division
- interfere with viral replication within cells
- are routinely used in nasal sprays for the common cold
-interfere with viral replication within cells
Complement proteins and antibodies coat a microorganism and provide binding sites, enabling macrophages and neutrophils to phagocytize the organism. This phenomenon is termed \_\_\_\_\_\_\_\_. agglutination diapedesis opsonization chemotaxis
opsonization
Innate immune system defenses include ________.
phagocytosis
Fever ________.
production is regulated by chemicals that reset the body’s thermostat to a higher setting
Natural killer (NK) cells
can kill cancer cells before the adaptive immune system is activated
Soluble proteins secreted by plasma cells are called antibodies.
True
Which of the areas seen the figure must be occupied by T lymphocytes, at least for a while, but is NOT required for the production of B lymphocytes?
Thymus
Proliferation of lymphocytes occurs immediately after which of these events?
activation
B lymphocytes develop immunocompetence in the ________
bone marrow
Which of the following should produce naturally acquired, active immunity?
recovering from the chicken pox
Which of the following best illustrates artificially acquired active humoral immunity? antivenoms infection antibodies received in breast milk vaccines
vaccines
Which of the following occurs when antibodies block specific sites on viruses or bacterial exotoxins? neutralization agglutination complement fixation and activation precipitation
neutralization
Which mechanism(s) of antibody action triggers the response of a plasma protein that will result in a membrane attack complex? complement activation neutralization precipitation agglutination
complement activation
Which mechanism(s) of antibody action result(s) in cell lysis?
complement activation
Why are children given vaccinations?
so that they will develop antibodies against various disease-causing pathogens