endocrine Flashcards
Function of endocrine glands
Lack ducts and release hormones into the blood or surrounding tissues. Since hormones travel in the extracellular fluid, they can act on cells that are quite a distance away from the original secreting endocrine gland
major endocrine organs and structures
pineal gland, hypothalamus, pituitary gland, thyroid gland, parathyroid glands, thymus, adrenal glands, pancreas, gonads,
what are the 2 basic categories of hormones?
water soluble (hydrophilic) and lipid soluble (hydrophobic)
water soluble hormones or hydrophilic tend to be
amino acids based water soluble proteins.
lipid soluble hormones are usually
steroids and derived from cholesterol
what are the category of structures that are fatty acids that don’t fit the typical description of a hormone. they don’t travel in blood they function more locally
prostaglandins
Our two categories of hormones act differently
True
When a hormone binds to a cell it alters the cell’s activityA hormone may increase or decrease a particular cell’s activity and the affect a given hormone has on a cell is specific to the cell, not the hormone. This is called
target cell
Hormones have 2 basic mechanisms of action depending on whether they are
water or lipid soluble
things that move readily across the cell membrane are
lipid soluble
the things that do not move easily over the cell membrane
water soluble molecules
Something that is polar,____ ______ go across the phospholipid by layer.
does not
for water soluble cells the receptors are on the _____ of the cell
outside
water soluble hormones start a cascade effect once they bind to their receptors this is called _________
second messenger system or cyclic AMP - two atp
The first horomone that bonds to water soluble cell is called
first messenger
The hormone is called the first messenger and its binding to a receptor causes the activation of a
G protein
The activated G protein actives the enzyme, adenylate cyclase, which takes ATP and forms cAMP, cyclic AMP. cAMP, this is called the
second messenger
the second messenger, then floats in the cell and activates another enzyme,
protein kinase
Protein kinases are a group of enzymes that add a phosphate group to another
protein
The second messenger system is an example of a
cascade effect
what is cAMP
Cyclic AMP - Intracellular second messenger that mediates the effects of the first (extracellular) messenger (hormone or neurotransmitter); formed from ATP by a plasma membrane enzyme (adenylate cyclase).
Cyclic AMP is the
most common 2nd messenger in the body
Once the hormone get attached to the receptor the reaction is very
FAST
all hydrophyllic hormones work
FAST
What is the most common 2nd messanger
Cyclic AMP
Lipid soluble hormones or hormones that are hydrophobic have recepter that are
inside the cell since the cell.
a steroid hormone goes right across the cell membrane and the nuclear membrane as well.
T
Where are the receptors for lipid soluble hormones?
The DNA itself.
Lipid soluble hormones can increase and decrease the trancription or translation
production of proteins
Lipid soluble hormones affect your
DNA and protein Synthesis
Effecting the synthesis of a protein takes
a long time
epinephrine works ______, cortisone steroid works ______
fast, slow
Water soluble hormones have a shorter half-life, a fast onset and a short duration
True
Lipid-soluble hormones have a longer half life, slow onset and a longer duration
True
3 major ways to stimulate a cell?
Humoral, neural, hormonal.
What is a humoral stimulus?
hormone release caused by altered levels of certain critical ions or nutrients
What is an example of humoral stimulus?
Perithyroid hormone is secreted in response to low blood calcium levels
What is a hormonal stimulation
When a hormone stimulates another hormone
What is the neural stimulus
hormone relased caused by neural input.
example of the nervous system being the stimuls?
When there is an increase in sympathetic stimulation we see an increase in epinephrine.
What gland is a good example of a hormonal stimulus?
thyroid gland.
A given hormone can bind to more than one cell and a given cell can bind more than one hormone
True
humoral response is when a hormone is secreted in response to
changes in blood levels of specific ion and nutrients.
a rise in insulin levels following elevated blood glucose levels is an example of what kind of stimuli?
humoral stimuli
neural stimuli is a classic example of what kind of innervation
sympathetic nervous system stimulation.
The pituitary gland is connected to the _______ via the _________
hypothalamus, infundibulum.
What are the two lobes of the pituitary gland?
posterior and anterior lobes.
The posterior pituitary is derived from _______ and is actually considered part of the ________
nervous tissue, brain
the posterior pituitary is connected to the hypothalamus via a
nerve tract
hormones are made by the hypothalamus and then stored by the
posterior pituitary
the neurohormones in the posterior pituitary are released upon
sns stimulation
what are the two neurohormones secreted by the posterior pituitary gland
ADH and Oxytocin
What is ADH and what does it do?
Antidiuretic hormone
Hormone produced by the hypothalamus and released by the posterior pituitary; stimulates the kidneys to reabsorb more water, reducing urine volume.
What does oxytocin do
Hormone synthesized in the hypothalamus and secreted by the posterior pituitary; stimulates contraction of the uterus during childbirth and the ejection of milk during nursing.
The connection between the hypothalamus and the anterior pituitary is one of a
portal system