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CEU - Farmacologia > Tema 30 Histamina y Serotonina > Flashcards

Tema 30 Histamina y Serotonina Flashcards

0
Q

¿Por qué no usamos agonistas histaminergicos?

A

No tiene utilidad clinica

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1
Q

Histamina, caracterizacion y receptores importantes

A

Es un nt autacoide que interviene en:
SNC
Procesos alergicos (liberandose en granulos de los mastocitos)
Secrecion acida gastrica (estimulacion sobre celulas parietales tras estimulacion por Ach)

Receptores mas importantes H1 y H2

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2
Q

Indicaciones antihistaminicos H1

A

Procesos alergicos

Efectos centrales

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3
Q

Contraindicaciones antagonistas H1

A

Efectos gastrointestinales

Efectos centrales

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4
Q

Antihistaminicos H1PRIMERA GENERACION

A

Prometazin

Difenhidramina

Clorfenamina

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5
Q

Antihistaminicos H1 segunda generacion

A

Loratadina

Ebastina

Mizolastina

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6
Q

Indicaciones antihistaminicos H2

A

Bloqueo gastrico:

Ulcera gastroduodenal
Esofagitis por reflujo
Gastritis

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7
Q

Contraindicaciones A H2

A

Efectos centrales

Efectos gastrointestinales

Muy bien tolerados en general

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8
Q

A H2

A

Cimetidina: POTENCIALES ALTERACIONES HORMONALES Y CONFUSION

Ranitidina

Famotidina

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9
Q

Serotonina, caracterizacion

A 
Agregacion plaquetaria
Peristaltismo GI
Tono vascular
Nocicepcion
\+ Efectos centrales ya conocidos

Receptores 5-HT1a7

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10
Q

Farmacos serotonina

A

Agonistas:

5HT1
5HT4

Antagonistas:

5HT2
5HT3

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11
Q

5 HT1 mecanismos

A

Inhiben liberacion de nt proinflamatorios, disminuyendo la inflamacion neurogenica

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12
Q

Indicaciones agonistas 5HT1

A

Migraña

Cefalea acuminosa

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13
Q

Farmacos agonistas 5HT1

A

Derivados ergoticos: dihidroergotamina

Triptanes

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14
Q

Derivados ergoticos, efectos adversos

A

Estimulacion de otros receptores que no son 5HT1: ergotismo

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15
Q

Triptanes: mecanismo de accion, efectos adversos

A

Son mas selectivos (5HT1b/d)

Vasoespasmo coronario

16
Q

Agonistas 5 HT 4 mecanismo de accion

A

liberacion acetilcolina en tracto GI, aumento del peristaltismo, fx procinetica, efecto bloqueante de receptores de dopamina: accion antiemetica

17
Q

Indicaciones agonistas 5HT4

A

Dispepsias

Gastroparesis diabetica

Reflujo gastroesofagico

18
Q

Efectos adversos A 5HT4

A

Derivados de la accion antidopaminergica central

19
Q

Farmacos A 5HT4

A

metoclorpamida

cinitaprida

Cleboprida

20
Q

Antagonistas 5-HT2, mecanismo de accion, indicaciones

A

Bloquean neuronas glucosensibles del hipotalamo ventrolateral. Anorexia, migrañas.

21
Q

Contraindicaciones AG 5HT2

A

Somnolencia

Alteraciones digestivas

22
Q

Farmacos AG 5HT2

A

Ciproheptadina

Pizotifeno

23
Q

AG 5HT3

A

Bloqueo receptores perifericos y centrales: accion antiemetica

24
Q

Indicaciones AG 5HT3

A

nauseas y vomitos

25
Q

Contraindicaciones AG 5HT3

A

Cefaleas

Alteraciones digestivas

26
Q

Farmacos AG 5HT3

A

Ondansetron

Tropisetron

CEU - Farmacologia (18 decks)

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