TCA (Tricyclic Antidepressants) Flashcards
1
Q
Name common TCA’s? (3rd line Mx) (4)
A
Amitriptyline, Lofepramine, Imapramine, Nortriptyline, Clomipramine
2
Q
Mechanism?
A
Prevents re-upatke of serotonin and NA
3
Q
Indication?
A
Moderate - Severe depression
Neuropathic pain
IBS
Poor sleep + appetite
4
Q
Contraindications?
A
CVD
Manic phase
Severe liver disease
5
Q
Side-effects?
A
Very toxic
Anit-muscarinic, anti-adrenergic, anti-histamine
Sedation, sexual dysfunction
Cardio: QT prolongation, arrhythmias
6
Q
Interactions?
A
Do not give with MAOi/SSRI
7
Q
Due to it toxicity, which patients should TCA’s not be given to?
A
Suicidal patients
