SSRI (Selective Serotonin Re-uptake Inhibitor)

Question 1

Name the 1st line SSRI’s? (2)

Answer 1

Fluoxetene

Citalopram

Question 2

What are the other SSRI’s? (2)

Answer 2

Sertraline

Paroxetine

Question 3

Mechanism of SSRI?

Answer 3

Prevents neuronal uptake of serotonin

Question 4

Indications? (6)

Answer 4

Moderate-severe depression
Anxiety/Phobia
Panic disorder
OCD
Bulimia nervosa

Question 5

Contraindications?

Answer 5

Manic episode

Epilepsy & peptic ulcer

Question 6

Side effects? (4)

Answer 6

May feel more motivated first (suicide risk)
GI disturbances: N&V, weight loss, diarrhoea
Sexual: lower libido,
Neuro: headache, anxiety

Question 7

Drug interactions?

Answer 7

Never give with TCA/MAOi = CARDIOTOXIC

Question 8

What do prescribe if increase risk of bleeds due warfarin and heparin?

Answer 8

Mirtazapine