MAOi (Monoamine Oxidase Inhibitor)

Question 1

Name the common MAOi? (4th line drug Mx for depression)

Answer 1

Maclobemide

Question 2

Mechanism?

Answer 2

Block degradation of MAO in synaptic cleft

Question 3

Indications?

Answer 3

Resistant depression (after SSRI, SNRI, TCA)

Question 4

Contraindications?

Answer 4

CVD
Poorly controlled HTN
Hyperthyroid

Question 5

Side effects? (4)

Answer 5

Rarely used due to poor tolerability + diet restrictions (cheese and yeast i.e. tyramine)
Risk of hypertensive crisis
Hepatotoxicity
Insomnia, anxiety, appetite suppression, weight gain