MAOi (Monoamine Oxidase Inhibitor) Flashcards

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1
Q

Name the common MAOi? (4th line drug Mx for depression)

A

Maclobemide

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2
Q

Mechanism?

A

Block degradation of MAO in synaptic cleft

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3
Q

Indications?

A

Resistant depression (after SSRI, SNRI, TCA)

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4
Q

Contraindications?

A

CVD
Poorly controlled HTN
Hyperthyroid

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5
Q

Side effects? (4)

A

Rarely used due to poor tolerability + diet restrictions (cheese and yeast i.e. tyramine)
Risk of hypertensive crisis
Hepatotoxicity
Insomnia, anxiety, appetite suppression, weight gain

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