TB Pharm Flashcards
What kind of bacteria are myobacteria?
Aerobic bacilli
How many of the 4 first line drugs are given during the intensive phase of TB and how long is this phase usually?
Give all 4 for 2 months.
How many of the 4 first lone drugs do you give for the continuation phase, which ones, and how long is the phase?
Give isoniazid and rifampin for 4 months.
What combo of drugs (which families) do you give for second line treatment if there is resistance to iso or rifampin?
Aminoglycoside, fluoro, any first line that remains to give, and one of the other drugs.
What two drugs are given for severe resistance?
Clofa and linezolid
What is the MOA of isoniazid and how is it activated?
It is a prodrug activated by KATG.
Takes out TB cell wall by taking out lnhA and KasA
What is the one serious adverse effect of Isoniazid?
Hepatitis
What is the MOA for rifampin?
Blocks RNA transcription by taking out TB RNA Polymerase
What drug can we switch to if a patient has TB and HIV?
Rifabutin
What is a good monotherapy or combo therapy for latent TB?
Isoniazid for mono
Isoniazid and rifapentine
What does rifampin do to CYP 450s
Induces them
What is the most important adverse effect of ethambutol?
Optic neuritis
Urine is red/orange, what drug is the patient on?
Rifampin
MOA for ethambutol?
Goes after TB cell wall
What TB do we use capreomycin for and what is its MOA?
Resistant.
Protein synthesis inhibitor
