Anti Fungal Pharm

Question 1

MOA for amphotericin B?

Answer 1

Complexes with ergosterol to take out fungal cell membrane

Question 2

Short term and long term adverse effect of amphotericin B?

Answer 2

Flu

Renal problems

Question 3

MOA of flucytosine?

Answer 3

Inhibits DNA and RNA synthesis

Question 4

Which fungus does flu go after and what is the one adverse effect?

Answer 4

C neoformans

Low blood products

Question 5

MOA of azoles?

Answer 5

Inhibits fungal cyp 450s

Question 6

What are two unique features of fluconazole?

Answer 6

Penetrates CSF and no activity against Aspergillus

Question 7

What are we using Itraconazole against?

Answer 7

Histo and blasto

Question 8

What are we using fluconazole against?

Answer 8

C meningitis

Question 9

What are we using voriconazole against?

Answer 9

Aspergillus

Question 10

What are we using posaconazole against and what is the unique identifier of this drug?

Answer 10

Mucormycosis

Broadest spectrum

Question 11

MOA for echinocandins and what are the two fungus they go after?

Answer 11

Inhibit glucagon synthase

Candida and Aspergillus

Question 12

Caspofungin goes after which of the two

Mica and anidula goes after which of the two

Answer 12

Aspergillus

Candida