targeted therapy

Question 1

rituximab

Answer 1

targets the CD20 antigen, used for treatment of many B cell lymphomas

Question 2

what are side effects of tumour specific monoclonal antibodies (like rituximab)

Answer 2

allergic reactions and TLS

Question 3

what is TLS

Answer 3

TLS is the tumor lysis syndrome, caused by the destruction of cells. due to this there is an release of LDH which causes uric acid to be made and thus renal failure

Question 4

ibritumomab/tiuxetan

Answer 4

radioactive parts are added to the immunoglobulins as therapy

Question 5

ADC

Answer 5

MMAE is added to the antibody

Question 6

which side effects can occur if you give ADC to a patient

Answer 6

MMAE polyneuropathy

Question 7

what are BiTE for drugs

Answer 7

cominbation of two different antibdoies which caueses T and B cells to be linked, after which the T cell can destroy the B cell

Question 8

what are CAR T cells for drugs

Answer 8

genes from multiple molecules are combined to make a neogene that is introduced into T cells via a virus, in order to kill the B cells

Question 9

what are side effects of CAR T cells

Answer 9

cytokine release syndrome, hypotension, fever, tachycardia and dyspnoea

Question 10

imatinib

Answer 10

tyrosine kinase inhibitor that can be used for CML

Question 11

midostaurin

Answer 11

FLT3 inhibitor used to treat patients with AML