G Flashcards
in which way can enchanced sensitivity be done
chemoradtiotherapy, biological agents, oxygen to tumor, hyperthermia
concomitant treatment
in same period
sequential treatment
chemotherapy and radiotherapy given after each other
what is the mechanism of action of chemoradiation
DNA damage to tumour cells are more fatal than in irradiation alone due to different modes of action for radiation and chemotherapy. also chemotherapy radiosentizes. and chemotherapy can treat hypoxic cells
what is a disatvantage of chemoradiation
there will be inhibition of post irradiation repai, due to that chemotherapy can inhibit nucleotide metabolism
chemoradiation is used only in curative treatment. it can be divided into three groups, which three
primary treatment, adjuvant treatment, neoadjucant treatment
what is stereotactic radiotherapy? for what is it used?
a percisely targeted radiation at much higher doses than normal. used for small metastases and inaccessible skull base tumours
bragg peak
when a proton looses all its energy
for what tumors is proton therapy mostly used
in children or chorodoma/chondrosarcoma (skull base and spine tumours)
which lungtumours tend to disseminate early in their development
SCLC
lungcancer from epithelial cells, associated with production of keratin, metastasize relatively late and usually caused by smoking
squamous cell carcinoma (NSCLC)
lungcancer from mucus secreting glandular cells, most common in non smokers, metastases are common.
adenocarcinoma (NSCLC)
lungcancer from neuroendocrine cells (APUD cells) often secrete polypeptide hormones
small cell carcinoma
what are typical sites fort a lung tumour to metastase to
kidney, prostate, breast, bone, GI tract, cervix or ovary
horner syndrome
caused by compression of C8/T1
